What is the travel distance from St. Louis to Panama City?

St. Louis and Panama City are 639 miles (1030 km) apart.

What are the departure and arrival stations when taking the bus from St. Louis to Panama City?

Buses going from St. Louis to Panama City begin their journey at Gateway Station and reach their destination at Panama City Greyhound Bus Station.

What are the best sights and things to do in Panama City?

Once in Panama City, you can start exploring the city and discover its surroundings. The top sights and things to do are Visit an Indigenous Tribe, The Biomuseo, Shopping, Panama Viejo and Panama Rainforest Discovery Center.

Bus St. Louis to Panama City from $100 | Refundable Tickets

Previously seen trips

Next departures for St. Louis to Panama City on November 7
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
1:45am	Gateway Station	1d 10h	12:35pm	Panama City Beach Station	No tags
1:45am	Gateway Station	1d 10h	12:35pm	Panama City Beach Station	No tags
1:45pm	Gateway Station	23h 55m	1:40pm	Panama City Beach Station	No tags
1:45am	Gateway Station	1d 10h	12:35pm	Panama City Beach Station	No tags
2:30am	Gateway Station	1d 11h	1:40pm	Panama City Beach Station	No tags

Get from St. Louis to Panama City

This route is served by bus only

The journey takes about 1 day, 5 hours 5 minutes and with fares starting at just $108, it presents an excellent value for a comfortable ride.

3bus per day

1d 5hAverage Duration

634 milesDistance

26kgCO₂ emissions

Compare bus companies

Greyhound

3.5/587,355 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in St. Louis and Panama City?

Stops in St. Louis

A - Gateway Station

Stops in Panama City

A - Panama City Greyhound Bus Station

Frequently asked questions about traveling from St. Louis to Panama City, US by bus

What is the travel distance from St. Louis to Panama City?
What are the departure and arrival stations when taking the bus from St. Louis to Panama City?
What are the best sights and things to do in Panama City?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/05

No data

11/06

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Today

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11/08

$100

11/09

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11/10

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11/11

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11/12

$110

The cheapest trip from St. Louis to Panama City, US was searched and found on Nov 8, 2025 with a price of $100

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Panama City, US, as early as possible.

You can expect to pay from $100 to $111 for a bus ticket from St. Louis to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at $100 which is on 2025-11-08.

Top traveled bus routes

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