Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Buffalo, NY (181 Ellicott St, Buffalo, NY 14203, United States) | No tags | ||||
Greyhound + FlixBus | Bus | Gateway Station | Buffalo (BUF) Airport | No tags | ||||
Greyhound + FlixBus | Bus | Gateway Station | Buffalo (BUF) Airport | No tags | ||||
| Bus | Gateway Station | Niagara Frontier Transportation Authority | No tags | ||||
| Bus | Gateway Station | Buffalo, NY (181 Ellicott St, Buffalo, NY 14203, United States) | No tags |
Compare 2 ways to go from St. Louis to Buffalo
Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 1 day, 8 hours 45 minutes and with fares starting at just $126, it presents an excellent value for a comfortable ride.
Where are the popular stops in St. Louis and Buffalo?
Stops in Buffalo
- B185 Ellicott St, Buffalo, NY 14203, USA
- C75 Exchange St, Buffalo, NY 14203, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from St. Louis to Buffalo, NY by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from St. Louis to Buffalo?
The cheapest bus tickets from St. Louis to Buffalo start from $126. The average price for this route is around $160. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from St. Louis to Buffalo?
The average bus trip duration from St. Louis to Buffalo is 1d 8h, covering a distance of 668 miles (1077 km). The quickest bus can get you there in 1d 1h and is operated by Greyhound.
Which bus companies service the St. Louis to Buffalo route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from St. Louis to Buffalo?
The earliest bus departs from St. Louis to Buffalo at 2:00am. And the latest bus departs at 1:55pm.
What are the CO₂ emissions for the bus trip from St. Louis to Buffalo?
A bus trip from St. Louis to Buffalo generates an estimated 27 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Buffalo, NY was searched and found on Nov 28, 2025 with a price of $155To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Buffalo, NY, as early as possible.
What's the cheapest way to go from St. Louis to Buffalo, NY?
The bus is the cheapest travel choice for this destination
