Next departures for St. Louis to Indianapolis on November 26
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Vehicle type
Departure time
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Bus
Gateway Station
Indianapolis Bus Station
CheapestFastest
Bus
Gateway Station
Indianapolis Bus Station
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Bus
Gateway Station
Indianapolis Bus Station
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Next departures for St. Louis to Indianapolis on November 27
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Departure time
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Bus
Gateway Station
Indianapolis Bus Station
CheapestFastest
Bus
Gateway Station
Indianapolis Bus Station
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Bus
Gateway Station
Indianapolis Bus Station
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Next departures for St. Louis to Indianapolis on November 28
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Vehicle type
Departure time
Departure location
Trip duration
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Arrival location
Recommended
Price and booking link
Bus
Gateway Station
Indianapolis Bus Station
CheapestFastest
Bus
Gateway Station
Indianapolis Bus Station
No tags
Bus
Gateway Station
Indianapolis Bus Station
No tags
Next departures for St. Louis to Indianapolis on November 29
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Vehicle type
Departure time
Departure location
Trip duration
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Recommended
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Bus
Gateway Station
Indianapolis Bus Station
Cheapest
Bus
Gateway Station
Indianapolis Bus Station
Fastest
Bus
Gateway Station
Indianapolis Bus Station
No tags
Next departures for St. Louis to Indianapolis on November 30
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Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Gateway Station
Indianapolis Bus Station
CheapestFastest
Bus
Gateway Station
Indianapolis Bus Station
No tags
Bus
Gateway Station
Indianapolis Bus Station
No tags
Last refresh of the prices: Today at 12:50 AM CST.
Compare 2 ways to go from St. Louis to Indianapolis
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 4 hours 25 minutes and with fares starting at just $40, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound St. Louis Indianapolis recent customer reviews
My Journey to Indianapolis was quite interesting. I really like the bus driver he was very approachable.
I appreciate that he got us to our destination in Indianapolis safely and early. I must say the bus was a old and I had to change seats several times due to water leaking on top of my head. Otherwise, I had no additional problems but that the bus needed to be upgraded.
Please let the bus driver know that he was great and thank him for the chat.
Sincerely,
Courtney
5 out of 5 stars
Courtney M.
I hope my round trip back home is better. My bus left 5 1/2 hours later than expected on the ride over to Indianapolis. Plus there were mo clear directions to the busport in St Louis. Even the terminal crew could not tell us where to catch the bus. The address given may have been the address in general for the whole airport. Signage unclear and we drove in circles looking for a busport which was actually across the hwy from the airport.
2 out of 5 stars
Linda T.
I was under the impression that we would get to our destination around 7:30 but didn’t make it until around 9. I understand there was a time change but I feel like the ticket should have reflected that time change if that was the case.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from St. Louis to Indianapolis by bus
How far is St. Louis from Indianapolis?
The distance separating St. Louis and Indianapolis is 230 miles (371 km).
What are the departure and arrival stations when taking the bus from St. Louis to Indianapolis?
Buses traveling from St. Louis to Indianapolis leave from Gateway Station and arrive at Greyhound Amtrak Station.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/23
$84
11/24
$68
Today
$74
11/26
$79
11/27
$64
11/28
$58
11/29
$60
11/30
$64
The cheapest trip from St. Louis to Indianapolis was searched and found on Nov 28, 2025 with a price of $58
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Indianapolis, as early as possible.
You can expect to pay from $58 to $149 for a bus ticket from St. Louis to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $58 which is on 2025-11-28.
What's the cheapest way to go from St. Louis to Indianapolis?
The bus is the cheapest travel choice for this destination
The cheapest trip from St. Louis to Indianapolis was searched and found on Nov 28, 2025 with a price of $58
The bus is the cheapest travel choice for this destination
