Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Jacksonville, FL to Panama City, US by bus
How far is Jacksonville from Panama City?
The distance separating Jacksonville and Panama City is 240 miles (387 km).
What are the departure and arrival stations when taking the bus from Jacksonville to Panama City?
Most of the buses traveling from Jacksonville to Panama City leave from Jacksonville Amtrak Station and arrive at Panama City Greyhound Bus Station. These are the most popular departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Panama City?
Once in Panama City, you can start exploring the city and discover its surroundings. The top sights and things to do are Inter-Oceanic Canal Muesum, Visit an Indigenous Tribe, Casco Antiguo, Panama Viejo and Bird Watching.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/21
$54
11/22
$54
Today
$57
11/24
$45
11/25
$52
11/26
$59
11/27
$49
11/28
No data
The cheapest trip from Jacksonville, FL to Panama City, US was searched and found on Nov 24, 2025 with a price of $45
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Jacksonville, FL to Panama City, US, as early as possible.
You can expect to pay from $45 to $89 for a bus ticket from Jacksonville, FL to Panama City, US based on the last 2 days. You can expect to find the cheapest price for the trip at $45 which is on 2025-11-24.
The cheapest trip from Jacksonville, FL to Panama City, US was searched and found on Nov 24, 2025 with a price of $45
