Bus Tickets from St. Louis to Tupelo

Next departures

Next departures for St. Louis to Tupelo on November 4
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
    		Gateway Station
    		Tupelo (Brothers Quick Stop)CheapestFastest

    Last refresh of the prices: Today at 8:44 AM CST.

    Accepted payments

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    Get from St. Louis to Tupelo

    This route is served by bus only

    The journey takes about 7 hours 5 minutes, and with fares starting at just US$81, it presents an excellent value for a comfortable ride.

    2bus per day
    7h 5mAverage Duration
    507 kmDistance
    13kgCO₂ emissions

    Bus St. Louis to Tupelo: Trip Overview

    Average Ticket PriceUS$93
    Average Bus Trip Duration7h 5m
    Number of daily buses2
    Earliest bus departure1:00am
    Distance506 km
    Latest bus departure4:00pm

    St. Louis to Tupelo Bus

    Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from St. Louis to Tupelo.

    We make sure you can find a bus service from St. Louis to Tupelo from the most reliable bus companies operating this trip.

    Whether it is cheap bus tickets or more luxurious buses going to Tupelo from St. Louis, we help you find what you're looking for based on how much of a budget you have.

    Frequently asked questions on the trip St. Louis - Tupelo

    1. What is the travel distance from St. Louis to Tupelo?

      St. Louis and Tupelo are 508 km (315 miles) apart.

    Find cheapest prices for buses

    Price is for a one-way ticket for one passenger and based on past searches.

    Best price found
    11-01
    No data
    11-02
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    Today
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    11-04
    US$88
    11-05
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    11-06
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    11-07
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    11-08
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    busbud logoThe cheapest trip from St. Louis to Tupelo was searched and found on Nov 4, 2025 with a price of US$88

    To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Tupelo, as early as possible.

    You can expect to pay from US$88 to US$88 for a bus ticket from St. Louis to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at US$88 which is on 2025-11-04.

    About Bus Travel

    Bus Travel Tips

    If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from St. Louis to Tupelo but it'll also be endearing to native speakers who will surely appreciate your effort.

    Start sightseeing the minute your bus leaves the station. If you're on the night bus from St. Louis to Tupelo, get comfy and count the stars.

    Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from St. Louis to Tupelo.

    Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Tupelo while indulging in miles on end of beautiful scenic views.

    Did you know?

    9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

    Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

    The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

    Will you be returning to St. Louis by bus?

    Bus from Tupelo to St. Louis

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