Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Lafayette Bus Stop | Gateway Station | Cheapest | ||||
 | Bus | Lafayette Bus Stop | Gateway Station | Fastest | ||||
| Bus | Lafayette Bus Stop | Gateway Station | No tags | ||||
 | Bus | Lafayette Bus Stop | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 10:00 PM EST.
Get from Lafayette to St. Louis
The journey takes about 9 hours 55 minutes, and with fares starting at just $64, it presents an excellent value for a comfortable ride.
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Where are the popular stops in Lafayette and St. Louis?
Frequently asked questions about travelling from Lafayette, IN to St. Louis by bus
What is the distance between Lafayette and St. Louis?
The distance covered from Lafayette to St. Louis is 354 km (220 miles).
What are the departure and arrival locations for buses traveling from Lafayette to St. Louis?
Buses traveling this route start their trip at CityBus Center, in Lafayette, and end it at Gateway Station, in St. Louis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lafayette, IN to St. Louis was searched and found on Nov 22, 2025 with a price of $77To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lafayette, IN to St. Louis, as early as possible.
You can expect to pay from $77 to $116 for a bus ticket from Lafayette, IN to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $77 which is on 2025-11-22.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
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