Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Chicago 95Th & Dan Ryan | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags |
Last refresh of the prices: Yesterday at 11:31 AM CST.
Get from Tupelo to Chicago
This route is served by bus only
The journey takes about 1 day, 35 minutes, and with fares starting at just $146, it presents an excellent value for a comfortable ride.
11bus per day
1d Average Duration
838 kmDistance
21kgCO₂ emissions
Compare bus companies
3.5 out of 5 stars3.5/587,386 reviews
Based on 87386 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $161
US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Frequently asked questions about travelling from Tupelo to Chicago by bus
How far is Tupelo from Chicago?
It's about 853 km (529 miles) from Tupelo to Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-18
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11-19
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Today
$288
11-21
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11-22
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11-23
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11-24
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11-25
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The cheapest trip from Tupelo to Chicago was searched and found on Nov 20, 2025 with a price of $288To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago, as early as possible.
