Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Chicago 95Th & Dan Ryan | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Greyhound Station | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: Today at 02:42 CST.
Get from Tupelo to Chicago
The journey takes about 1 day, 35 minutes, and with fares starting at just £79, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87391 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £88
Frequently asked questions about travelling by bus from Tupelo to Chicago
What's the distance between Tupelo and Chicago by coach?
The distance between Tupelo and Chicago by coach is approximately 529 miles (853 km).
How can I travel from Tupelo to Chicago avoiding air travel?
You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Chicago was searched and found on 24 Nov 2025 with a price of £175To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago as early as possible.
You can expect to pay from £175 to £272 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £175, which is on 2025-11-24.
