Bus Tickets from Tupelo to Chicago

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TodayJun 23
from $121
TomorrowJun 24
WedJun 25
from $115
ThuJun 26
from $148
FriJun 27
SatJun 28
SunJun 29
MonJun 30
from $140

Cheap buses leaving Wednesday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: June 25 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: June 26 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: June 25 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: June 25 at
    Destination city: Chicago
    Destination location: Chicago 95Th & Dan Ryan
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 25 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: June 25 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: June 25 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: June 26 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: June 25 at
    Departure city: Tupelo
    Departure location: Tupelo (Brothers Quick Stop)
    Arrival time: June 26 at
    Destination city: Chicago
    Destination location: Downtown Greyhound Station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:

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Bus Tupelo to Chicago: Trip Overview

Average ticket price$139
Average bus trip duration1d
Number of daily buses9.823529411764705
Earliest bus departure5:35am
Distance530 miles (854 km)
Latest bus departure11:15pm

Tupelo to Chicago Bus

With Busbud, comparing and booking tickets for a bus from Tupelo to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

We make sure you can find a bus service from Tupelo to Chicago from the most reliable bus companies operating this trip.

Discover how much the bus trip from Tupelo to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip Tupelo - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
06/21
$105
06/22
$189
Today
$142
06/24
No data
06/25
$109
06/26
$140
06/27
$112
06/28
$109
busbud logoThe cheapest trip from Tupelo to Chicago was searched and found on Jun 21, 2025 with a price of $105

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Chicago, as early as possible.

You can expect to pay from $105 to $235 for a bus ticket from Tupelo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2025-06-25.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while traveling from Tupelo to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Tupelo to Chicago, get comfy and count the stars.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from Tupelo to Chicago will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tupelo to Chicago.

Did you know?

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to Tupelo by bus?

Bus from Tupelo to Chicago

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