Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tupelo to New York City by bus
What is the distance between Tupelo and New York City?
The distance separating Tupelo and New York City is 918 miles (1480 km).
What are the best sights and things to do in New York City?
Once in New York City, you can start exploring the city and discover its surroundings. The top sights and things to do are Times Square, Central Park, 9/11 Tribute Center, Whitney Museum of American Art and Intrepid Sea, Air & Space Museum.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/25
$254
11/26
$171
Today
$251
11/28
No data
11/29
$269
11/30
$218
12/01
$177
12/02
No data
The cheapest trip from Tupelo to New York City was searched and found on Nov 26, 2025 with a price of $171
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to New York City, as early as possible.
You can expect to pay from $171 to $269 for a bus ticket from Tupelo to New York City based on the last 2 days. You can expect to find the cheapest price for the trip at $177 which is on 2025-12-01.