Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Gray & Smith | Cheapest | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Gray & Smith | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | No tags |
Last refresh of the prices: Today at 11:06 AM CST.
Get from Tupelo to Houston
The journey takes about 23 hours 15 minutes and with fares starting at just $104, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Tupelo Houston recent customer reviews
Bus was late bc of the snow storm..But there was no heat and the bus broke down 4x on way to memphis.. The bus driver held all passengers pretty much hostage . Even the lady with her baby that was freezing . We were stuck in a traffic jam not moving for almost an hour.The bus driver should took the inhumane conditions seriously since everyone was freezing with no heat
Alvin J.
Frequently asked questions about traveling from Tupelo to Houston, US by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Houston, US was searched and found on Nov 19, 2025 with a price of $143To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Houston, US, as early as possible.
You can expect to pay from $143 to $249 for a bus ticket from Tupelo to Houston, US based on the last 2 days. You can expect to find the cheapest price for the trip at $155 which is on 2025-11-22.
