Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | Cheapest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Gray & Smith | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Houston Bus Station | No tags |
Last refresh of the prices: Last Monday at 11:38 PM CST.
Get from Tupelo to Houston
The journey takes about 23 hours 40 minutes and with fares starting at just $116, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Tupelo Houston recent customer reviews
Bus was late bc of the snow storm..But there was no heat and the bus broke down 4x on way to memphis.. The bus driver held all passengers pretty much hostage . Even the lady with her baby that was freezing . We were stuck in a traffic jam not moving for almost an hour.The bus driver should took the inhumane conditions seriously since everyone was freezing with no heat
Alvin J.
Frequently asked questions about traveling from Tupelo to Houston, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Houston?
The cheapest bus tickets from Tupelo to Houston start from $116. The average price for this route is around $162. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Houston?
The average bus trip duration from Tupelo to Houston is 23h 40m, covering a distance of 499 miles (804 km). The quickest bus can get you there in 17h 55m and is operated by Greyhound.
Which bus companies service the Tupelo to Houston route?
Several major train operators operate on this route with 11 trains available per day.
What is the earliest and latest departure time for the bus from Tupelo to Houston?
The earliest bus departs from Tupelo to Houston at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Houston?
A bus trip from Tupelo to Houston generates an estimated 20 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Houston, US was searched and found on Jan 12, 2026 with a price of $109To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Houston, US, as early as possible.
You can expect to pay from $109 to $139 for a bus ticket from Tupelo to Houston, US based on the last 2 days. You can expect to find the cheapest price for the trip at $109 which is on 2026-01-12.
