Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Transit Center | Cheapest | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Transit Center | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | No tags |
Last refresh of the prices: Today at 4:52 AM CST.
Get from Tupelo to Indianapolis
The journey takes about 21 hours 10 minutes and with fares starting at just $105, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Tupelo to Indianapolis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Tupelo to Indianapolis?
The cheapest bus tickets from Tupelo to Indianapolis start from $105. The average price for this route is around $149. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Tupelo to Indianapolis?
The average bus trip duration from Tupelo to Indianapolis is 21h 10m, covering a distance of 407 miles (655 km). The quickest bus can get you there in 13h 30m and is operated by Greyhound.
Which bus companies service the Tupelo to Indianapolis route?
Several major train operators operate on this route with 5 trains available per day.
What is the earliest and latest departure time for the bus from Tupelo to Indianapolis?
The earliest bus departs from Tupelo to Indianapolis at 5:35am. And the latest bus departs at 11:15pm.
What are the CO₂ emissions for the bus trip from Tupelo to Indianapolis?
A bus trip from Tupelo to Indianapolis generates an estimated 16 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Indianapolis was searched and found on Dec 3, 2025 with a price of $98To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Indianapolis, as early as possible.
You can expect to pay from $98 to $256 for a bus ticket from Tupelo to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $98 which is on 2025-12-03.
