Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Transit Center | Cheapest | ||||
 | Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | Fastest | ||||
| Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tupelo (Brothers Quick Stop) | Downtown Transit Center | No tags | ||||
| Bus | Tupelo (Brothers Quick Stop) | Indianapolis Bus Station | No tags |
Last refresh of the prices: Today at 04:52 CST.
Get from Tupelo to Indianapolis
The journey takes about 21 hours 10 minutes, and with fares starting at just £81, it presents an excellent value for a comfortable ride.
Compare bus companies
Based on 87408 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £81
Frequently asked questions about travelling by bus from Tupelo to Indianapolis
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Tupelo to Indianapolis?
The cheapest coach tickets from Tupelo to Indianapolis start from £81. The average price for this route is around £115. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Tupelo to Indianapolis?
The average bus journey time from Tupelo to Indianapolis is 21h 10m, covering a distance of 407 miles. The fastest bus can take you there in 13h 30m and is operated by Greyhound.
Which bus companies service the Tupelo to Indianapolis route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Tupelo to Indianapolis?
The earliest bus departs from Tupelo to Indianapolis at 05:35. And the latest bus departs at 23:15.
What are the CO₂ emissions for the bus trip from Tupelo to Indianapolis?
A bus journey from Tupelo to Indianapolis produces an estimated 16 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tupelo to Indianapolis was searched and found on 3 Dec 2025 with a price of £76To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tupelo to Indianapolis as early as possible.
You can expect to pay from £76 to £199 for a bus ticket from Tupelo to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at £76, which is on 2025-12-03.
