Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gateway Station | Lafayette Bus Stop | No tags | ||||
| Bus | Gateway Station | Lafayette Bus Stop | No tags | ||||
| Bus | Gateway Station | Lafayette Bus Stop | No tags | ||||
| Bus | Gateway Station | Lafayette Bus Stop | No tags | ||||
| Bus | Gateway Station | Lafayette Bus Stop | No tags |
Compare 2 ways to go from St. Louis to Lafayette
Among the sustainable travel choices, the bus stands out as a good way to reach Lafayette. The journey takes about 9 hours 5 minutes, and with fares starting at just $57, it presents an excellent value for a comfortable ride.
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Where are the popular stops in St. Louis and Lafayette?
Frequently asked questions about travelling from St. Louis to Lafayette, IN by bus
What is the travel distance from St. Louis to Lafayette?
It's about 354 km (220 miles) from St. Louis to Lafayette.
What are the departure and arrival locations for buses traveling from St. Louis to Lafayette?
Buses departing from Gateway Station in St. Louis will take you to CityBus Center in Lafayette.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from St. Louis to Lafayette, IN was searched and found on Nov 18, 2025 with a price of $50To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Lafayette, IN, as early as possible.
You can expect to pay from $50 to $162 for a bus ticket from St. Louis to Lafayette, IN based on the last 2 days. You can expect to find the cheapest price for the trip at $51 which is on 2025-11-19.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from St. Louis to Lafayette, IN?
The bus is the cheapest travel choice for this destination
