What is the distance between Indianapolis and St. Louis?

The distance between Indianapolis and St. Louis is approximately 371 km (230 miles).

What are the departure and arrival locations for buses traveling from Indianapolis to St. Louis?

Buses departing from Greyhound Amtrak Station in Indianapolis will take you to Gateway Station in St. Louis.

Bus Indianapolis to St. Louis from $47 | Refundable Tickets

Next departures

Next departures for Indianapolis to St. Louis on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
		8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	CheapestFastest

Next departures for Indianapolis to St. Louis on November 22
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:30am	Indianapolis Bus Station	3h 55m	6:25am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on November 23
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:30am	Indianapolis Bus Station	3h 55m	6:25am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on November 24
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:30am	Indianapolis Bus Station	3h 55m	6:25am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on November 25
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:30am	Indianapolis Bus Station	3h 55m	6:25am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on November 26
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:30am	Indianapolis Bus Station	3h 55m	6:25am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on November 27
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:30am	Indianapolis Bus Station	3h 55m	6:25am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Next departures for Indianapolis to St. Louis on November 28
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
3:30am	Indianapolis Bus Station	3h 55m	6:25am	Gateway Station	CheapestFastest
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
11:25am	Indianapolis Bus Station	4h 55m	3:20pm	Gateway Station	No tags
6:40am	Greyhound Amtrak Station	6h 21m	12:01pm	Gateway Station	No tags
8:05pm	Indianapolis Bus Station	4h 20m	11:25pm	Gateway Station	No tags

Last refresh of the prices: Yesterday at 10:29 AM EST.

Compare 2 ways to go from Indianapolis to St. Louis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 4 hours 20 minutes, and with fares starting at just $60, it presents an excellent value for a comfortable ride.

3bus per day

4h 20mAverage Duration

371 kmDistance

9kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$60 - $280	Average Duration4h 20m	CO₂ emissions 9kg CO₂e
Train	Average Price$94 - $245	Average Duration17h 23m	CO₂ emissions 34kg CO₂e

Where are the popular stops in Indianapolis and St. Louis?

Stops in Indianapolis

A
Greyhound Amtrak Station
350 S Illinois St, Indianapolis, IN 46225
Visit page

Stops in St. Louis

A
Gateway Station
430 S 15th St, St Louis, MO 63103
Visit page

Compare bus companies

Greyhound

3.5/587,387 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87387 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $60

Greyhound Indianapolis St. Louis recent customer reviews

The bus had some problems. Air conditioning was malfunctioning, and none of the outlets worked. There was also considerable damage to the seats that should have been repaired. The counter clerk was very friendly and helpful, but the bus driver seemed to be in a very bad mood and possibly ill, loudly coughing up phlegm the entire trip, and he gave us no indication of how late the bus was going to arrive. I will not ride Greyhound again if I can possibly avoid it.

Tremain X.

September 25, 2019

The 3:15 bus never arrived so I was forced to wait 6 hours at the station for the next departure. This was very poorly communicated to passengers and no effort was made for any sort of reimbursement. I will absolutely never use Greyhound again.

Matthew N.

August 16, 2018

Amtrak

4/55,597 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Burlington Trailways

4/520 reviews

Staff5

Timeliness5

Cleanliness5

Wifi5

FlixBus

3.5/511,391 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Indianapolis to St. Louis by bus

What is the distance between Indianapolis and St. Louis?
The distance between Indianapolis and St. Louis is approximately 371 km (230 miles).
What are the departure and arrival locations for buses traveling from Indianapolis to St. Louis?
Buses departing from Greyhound Amtrak Station in Indianapolis will take you to Gateway Station in St. Louis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-19

$80

11-20

$122

Today

$87

11-22

$87

11-23

$80

11-24

$82

11-25

$87

11-26

$90

The cheapest trip from Indianapolis to St. Louis was searched and found on Nov 19, 2025 with a price of $80

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to St. Louis, as early as possible.

You can expect to pay from $80 to $250 for a bus ticket from Indianapolis to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $80 which is on 2025-11-23.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.