Next departures for Chicago to St. Louis on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures for Chicago to St. Louis on December 2
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
CheapestFastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Last refresh of the prices: Today at 4:15 PM CST.
Compare 2 ways to go from Chicago to St. Louis
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 5 hours 1 minute, and with fares starting at just $43, it presents an excellent value for a comfortable ride.
According to 32 reviews, Greyhound received a 3.3-star rating for this journey. Travellers were especially satisfied with the staff and the timeliness, but some complained about the ticket access. Greyhound ticket prices on this trip start at $54
Greyhound Chicago St. Louis recent customer reviews
It was an awful experience never I will book a flixbus. Bus did not come on time it was more than 6 hours late and no one can ready for the replay. Zero services.
1 out of 5 stars
Harshil Jagdish U.
Workers at the Greyhound station of Chicago and St. Louis were very helpful. Not the friendliest, but helpful indeed. The bus itself was over 2hrs late with no explanation and we were not told how long of a delay it would be upon initial announcement.
2 out of 5 stars
Amber H.
Our bus was supposed to leave Chicago at 1:30 in the morning, we did not leave until 5:30. It was very late and a huge inconvenience. The station was also very dirty, so there was not clean places to sit and wait.
Based on 11439 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the WiFi. FlixBus ticket prices on this trip start at $59
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travellers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at $263
Customers have shared positive experiences regarding their recent trips. They appreciated the quiet and smooth rides, comfortable seating with ample space to relax or sleep, and efficient senior customer assistance. Additionally, travelers noted that the train was very clean and enjoyed improved food quality compared to previous journeys.
Amtrak Chicago St. Louis recent customer reviews
My trip experience was very quiet and smooth. I was in comfort and had plenty of space where I could relax and get some sleep. My trip was 4 1/2 hours.
4 out of 5 stars
Rosemarie H.
Everything was fine, senior customer assistance, smooth ride,nice seating all good
5 out of 5 stars
Samuel S.
The trip was the fastest available option. The train was very clean. I like how they announced for people to respect others and keep noise down by using headphones etc. I believe there was Wi-Fi available, I didn’t need though.
It was a great Amtrak experience I had compared to my past Amtrak travels, I remember from more than 2-3 years back. The food was also better than I remembered.
Frequently asked questions about travelling from Chicago to St. Louis by bus
What is the travel distance from Chicago to St. Louis?
The distance between Chicago and St. Louis is approximately 419 km (260 miles).
What are the departure and arrival locations for buses traveling from Chicago to St. Louis?
Buses departing from Downtown Greyhound Station in Chicago will take you to Gateway Station in St. Louis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-22
$121
11-23
$109
Today
$103
11-25
$99
11-26
$99
11-27
$74
11-28
$71
11-29
$74
The cheapest trip from Chicago to St. Louis was searched and found on Nov 28, 2025 with a price of $71
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to St. Louis, as early as possible.
You can expect to pay from $71 to $236 for a bus ticket from Chicago to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $71 which is on 2025-11-28.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Chicago to St. Louis was searched and found on Nov 28, 2025 with a price of $71
