Bus from Chicago to St. Louis: Tickets & Timetables
Next bus departures
Next departures from Chicago to St. Louis on 26 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures from Chicago to St. Louis on 27 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures from Chicago to St. Louis on 28 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures from Chicago to St. Louis on 29 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures from Chicago to St. Louis on 30 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures from Chicago to St. Louis on 1 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Gateway Station
Cheapest
Bus
Chicago 95Th & Dan Ryan
Gateway Station
Fastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Next departures from Chicago to St. Louis on 2 December
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Gateway Station
CheapestFastest
Bus
Downtown Greyhound Station
Gateway Station
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Bus
Downtown Greyhound Station
Gateway Station
No tags
Last refresh of the prices: Today at 17:05 CST.
Compare 2 ways to travel from Chicago to St. Louis
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 5 hours 1 minute and with fares starting at just £23, it presents an excellent value for a comfortable ride.
According to 32 reviews, Greyhound received a 3.3-star rating for this journey. Travellers were especially satisfied with the staff and the timeliness, but some complained about the ticket access. Greyhound ticket prices on this trip start at £29
Greyhound Chicago St. Louis recent customer reviews
It was an awful experience never I will book a flixbus. Bus did not come on time it was more than 6 hours late and no one can ready for the replay. Zero services.
1 out of 5 stars
Harshil Jagdish U.
Workers at the Greyhound station of Chicago and St. Louis were very helpful. Not the friendliest, but helpful indeed. The bus itself was over 2hrs late with no explanation and we were not told how long of a delay it would be upon initial announcement.
2 out of 5 stars
Amber H.
Our bus was supposed to leave Chicago at 1:30 in the morning, we did not leave until 5:30. It was very late and a huge inconvenience. The station was also very dirty, so there was not clean places to sit and wait.
Based on 11443 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £32
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travellers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at £141
Customers have shared positive experiences regarding their recent trips. They appreciated the quiet and smooth rides, comfortable seating with ample space to relax or sleep, and efficient senior customer assistance. Additionally, travelers noted that the train was very clean and enjoyed improved food quality compared to previous journeys.
Amtrak Chicago St. Louis recent customer reviews
My trip experience was very quiet and smooth. I was in comfort and had plenty of space where I could relax and get some sleep. My trip was 4 1/2 hours.
4 out of 5 stars
Rosemarie H.
Everything was fine, senior customer assistance, smooth ride,nice seating all good
5 out of 5 stars
Samuel S.
The trip was the fastest available option. The train was very clean. I like how they announced for people to respect others and keep noise down by using headphones etc. I believe there was Wi-Fi available, I didn’t need though.
It was a great Amtrak experience I had compared to my past Amtrak travels, I remember from more than 2-3 years back. The food was also better than I remembered.
Frequently asked questions about travelling by bus from Chicago to St. Louis
How far is St. Louis from Chicago by coach?
The journey from Chicago to St. Louis by coach covers an approximate distance of 260 miles (419 km).
Is there a way to reach St. Louis from Chicago without flying?
You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
23/11
£59
24/11
£56
Today
£62
26/11
£56
27/11
£40
28/11
£39
29/11
£39
30/11
£82
The cheapest trip from Chicago to St. Louis was searched and found on 28 Nov 2025 with a price of £39
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to St. Louis as early as possible.
You can expect to pay from £39 to £159 for a bus ticket from Chicago to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at £39, which is on 2025-11-28.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Chicago to St. Louis was searched and found on 28 Nov 2025 with a price of £39
