Next departures from St. Louis to Chicago on 21 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Next departures from St. Louis to Chicago on 22 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures from St. Louis to Chicago on 23 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Next departures from St. Louis to Chicago on 24 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Next departures from St. Louis to Chicago on 25 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Next departures from St. Louis to Chicago on 26 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Chicago 95Th & Dan Ryan
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures from St. Louis to Chicago on 27 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Gateway Station
Downtown Greyhound Station
No tags
Next departures from St. Louis to Chicago on 28 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Gateway Station
Downtown Greyhound Station
Cheapest
Gateway Station
Chicago 95Th & Dan Ryan
Fastest
Gateway Station
Chicago (Union Station), IL
No tags
Gateway Station
Downtown Greyhound Station
No tags
Gateway Station
537-517 W. Jackson Blvd
No tags
Last refresh of the prices: Today at 09:05 CST.
Compare 2 ways to travel from St. Louis to Chicago
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach Chicago. The journey takes about 5 hours 5 minutes and with fares starting at just £23, it presents an excellent value for a comfortable ride.
Based on 11390 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £30
According to 27 reviews, Greyhound received a 3.1-star rating for this journey. Travellers were especially satisfied with the temperature and the departure location, but some complained about the value for money. Greyhound ticket prices on this trip start at £30
Greyhound St. Louis Chicago recent customer reviews
My trip was changed then cancelled and the next bus took 2 hrs . My connection to complete my trip made me arrive at my final destination at 4 am to an empty station where I couldn't get any assistance. Couldn't get a taxi at that hour there. It was a very horrible experience.
1 out of 5 stars
Raydell W.
My first time from along time to many stops little confusing if we were close or what time we really will be in Chicago in all Ok!
3 out of 5 stars
Shelia S.
Very professional and courteous. Actually, quite a bit more professional and less stressful than air travel presently. Pleasantly surprised!
Based on 20 reviews, the company was rated 4.2 stars on Busbud. Travellers were especially satisfied with the staff and the timeliness but often complained with the ticket access. Burlington Trailways ticket prices on this trip start at £143
Users have praised the service for being on time, comfortable, and convenient with friendly conductors. However, there were concerns about inconsistent behavior from staff towards passengers of different races during ticket checks and upon arrival.
Amtrak St. Louis Chicago recent customer reviews
Smooth ride. The man who did our tickets from St. Louis we noticed after checking white people's tickets he said thanks and have a great day. To black people he said nothing. Then upon arriving in Chicago that man offered no one a hand down or said goodbye.
4 out of 5 stars
Yvonne H.
Fabulous! Train is the way to go for this distance!! On time, comfortable, friendly conductors, and SO convenient!
5 out of 5 stars
Kendra H.
Good but train was cancelled and coming with bus. I pay too much money
Frequently asked questions about travelling by bus from St. Louis to Chicago
How far is Chicago from St. Louis by coach?
The distance between St. Louis and Chicago by coach is approximately 260 miles (419 km).
Is there a way to reach Chicago from St. Louis without flying?
You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
19/11
£59
20/11
£96
Today
£78
22/11
£43
23/11
£44
24/11
£41
25/11
£41
26/11
£41
The cheapest trip from St. Louis to Chicago was searched and found on 24 Nov 2025 with a price of £41
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Chicago as early as possible.
You can expect to pay from £41 to £258 for a bus ticket from St. Louis to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £41, which is on 2025-11-24.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from St. Louis to Chicago was searched and found on 24 Nov 2025 with a price of £41
