Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 537-517 W. Jackson Blvd | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus | 537-517 W. Jackson Blvd | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus | Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags |
Get from Chicago to Tupelo
This route is served by bus only
The journey takes about 20 hours 55 minutes, and with fares starting at just $129, it presents an excellent value for a comfortable ride.
7bus per day
20h 55mAverage Duration
838 kmDistance
21kgCO₂ emissions
Compare bus companies
US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad
Frequently asked questions about travelling from Chicago to Tupelo by bus
How far is Chicago from Tupelo?
The distance covered from Chicago to Tupelo is 853 km (529 miles).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11-19
$208
11-20
$222
Today
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11-22
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11-23
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11-24
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11-25
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11-26
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The cheapest trip from Chicago to Tupelo was searched and found on Nov 19, 2025 with a price of $208To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo, as early as possible.
