Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | Cheapest | ||||
 | Bus | Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus | Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | No tags | ||||
| Bus | 537-517 W. Jackson Blvd | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Today at 6:27 PM CST.
Get from Chicago to Tupelo
The journey takes about 21 hours 45 minutes, and with fares starting at just $175, it presents an excellent value for a comfortable ride.
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Frequently asked questions about travelling from Chicago to Tupelo by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Tupelo?
The cheapest bus tickets from Chicago to Tupelo start from $175. The average price for this route is around $249. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Tupelo?
The average bus travel time from Chicago to Tupelo is 21h 45m, covering a distance of 855 km. The quickest bus can get you there in 12h 10m and is operated by Greyhound.
Which bus companies service the Chicago to Tupelo route?
What are the earliest and latest departure times for the bus from Chicago to Tupelo?
The earliest bus departs from Chicago to Tupelo at 5:45am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to Tupelo?
A bus trip from Chicago to Tupelo generates an estimated 21 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Chicago to Tupelo?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87463 reviews.
Which bus company has the best Wi-Fi from Chicago to Tupelo?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Chicago to Tupelo?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to Tupelo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Tupelo was searched and found on Jan 12, 2026 with a price of $196To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo, as early as possible.
You can expect to pay from $196 to $196 for a bus ticket from Chicago to Tupelo based on the last 2 days. You can expect to find the cheapest price for the trip at $196 which is on 2026-01-12.
