Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | Cheapest | ||||
| Bus | Downtown Greyhound Station | Tupelo (Brothers Quick Stop) | Fastest | ||||
| Bus | 537-517 W. Jackson Blvd | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Tupelo (Brothers Quick Stop) | No tags |
Last refresh of the prices: Yesterday at 09:42 CST.
Get from Chicago to Tupelo
The journey takes about 16 hours 15 minutes, and with fares starting at just £69, it presents an excellent value for a comfortable ride.
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Frequently asked questions about travelling by bus from Chicago to Tupelo
What's the distance between Chicago and Tupelo by coach?
The distance between Chicago and Tupelo by coach is approximately 529 miles (853 km).
How can I travel from Chicago to Tupelo avoiding air travel?
You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Tupelo was searched and found on 26 Nov 2025 with a price of £152To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Tupelo as early as possible.
