Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Detroit Bus Station | Gateway Station | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Detroit Bus Station | Gateway Station | Fastest | ||||
| Bus | Detroit Bus Station | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 1:18 PM EST.
Compare 2 ways to go from Detroit to St. Louis
Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 13 hours 41 minutes, and with fares starting at just $108, it presents an excellent value for a comfortable ride.
Where are the popular stops in Detroit and St. Louis?
Compare bus companies
Frequently asked questions about travelling from Detroit, MI to St. Louis by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Detroit to St. Louis?
The cheapest bus tickets from Detroit to St. Louis start from $101. The average price for this route is around $140. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Detroit to St. Louis?
The average bus travel time from Detroit to St. Louis is 15h 50m, covering a distance of 731 km. The quickest bus can get you there in 12h 25m and is operated by FlixBus.
Which bus companies service the Detroit to St. Louis route?
What are the earliest and latest departure times for the bus from Detroit to St. Louis?
The earliest bus departs from Detroit to St. Louis at 6:40am. And the latest bus departs at 11:25pm.
What are the CO₂ emissions for the bus trip from Detroit to St. Louis?
A bus trip from Detroit to St. Louis generates an estimated 18 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Detroit to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Detroit to St. Louis?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Detroit to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Detroit to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Detroit, MI to St. Louis was searched and found on Dec 3, 2025 with a price of $104To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to St. Louis, as early as possible.
You can expect to pay from $104 to $534 for a bus ticket from Detroit, MI to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $104 which is on 2025-12-03.
What's the cheapest way to go from Detroit, MI to St. Louis?
The bus is the cheapest travel choice for this destination
