Bus from Detroit, MI to St. Louis: Tickets & Timetables
Next bus departures
Next departures from Detroit to St. Louis on 26 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Detroit Bus Station
Gateway Station
CheapestFastest
Next departures from Detroit to St. Louis on 27 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Detroit Bus Station
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Fastest
Bus
Detroit Bus Station
Gateway Station
No tags
Next departures from Detroit to St. Louis on 28 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
CheapestFastest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
No tags
Bus
Detroit Bus Station
Gateway Station
No tags
Next departures from Detroit to St. Louis on 29 November
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Cheapest
Greyhound Lines, Inc. + FlixBus
Bus
Detroit Bus Station
Gateway Station
Fastest
Bus
Detroit Bus Station
Gateway Station
No tags
Last refresh of the prices: Yesterday at 18:11 EST.
Compare 2 ways to travel from Detroit to St. Louis
We recommend taking the train
Among the sustainable travel choices, the train stands out as a good way to reach St. Louis. The journey takes about 13 hours 41 minutes and with fares starting at just £58, it presents an excellent value for a comfortable ride.
Based on 87397 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at £55
Based on 11452 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the staff but often complained with the Wi-Fi. FlixBus ticket prices on this trip start at £63
Frequently asked questions about travelling by bus from Detroit, MI to St. Louis
What's the distance between Detroit and St. Louis by coach?
The distance between Detroit and St. Louis by coach is approximately 454 miles (733 km).
What is the best way to go from Detroit to St. Louis without flying?
You have the option to select the coach for your journey on this route. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
24/11
£141
25/11
£205
Today
£164
27/11
£92
28/11
£89
29/11
£158
30/11
£80
01/12
£73
The cheapest trip from Detroit, MI to St. Louis was searched and found on 1 Dec 2025 with a price of £73
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to St. Louis as early as possible.
You can expect to pay from £73 to £205 for a bus ticket from Detroit, MI to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at £73, which is on 2025-12-01.
What's the cheapest way to go from Detroit, MI to St. Louis?
The bus is the cheapest travel choice for this destination
The cheapest trip from Detroit, MI to St. Louis was searched and found on 1 Dec 2025 with a price of £73
The bus is the cheapest travel choice for this destination
