Bus Tickets from Columbia, MO to Knoxville, TN

Previously seen trips

Next departures for Columbia to Knoxville on November 3
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound
    		Midway Truck Plaza Bus Stop
    		Knoxville Bus StationNo tags
    Greyhound
      		Columbia Wabash Station
      		Knoxville Bus StationNo tags
      Greyhound
        		Midway Truck Plaza Bus Stop
        		Knoxville Bus StationNo tags
        Greyhound
          		Columbia Wabash Station
          		Knoxville Bus StationNo tags
          Greyhound
            		Midway Truck Plaza Bus Stop
            		Knoxville Bus StationNo tags

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            Get from Columbia to Knoxville

            This route is served by bus only

            The journey takes about 22 hours 40 minutes and with fares starting at just $67, it presents an excellent value for a comfortable ride.

            2bus per day
            22h 40mAverage Duration
            505 milesDistance
            20kgCO₂ emissions

            Bus Columbia, MO to Knoxville, TN: Trip Overview

            Average ticket price$67
            Average bus trip duration22h 40m
            Number of daily buses2
            Earliest bus departure8:05pm
            Distance505 miles (814 km)
            Latest bus departure8:35pm

            Columbia to Knoxville Bus

            With Busbud, comparing and booking tickets for a bus from Columbia to Knoxville is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            We make it our job to connect you with the most dependable bus companies that cover bus service from Columbia to Knoxville.

            Whether it is cheap bus tickets or more luxurious buses going to Knoxville from Columbia, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions for your trip Columbia, MO - Knoxville, TN

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            10/31
            No data
            11/01
            $59
            Today
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            11/03
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            11/04
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            11/05
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            11/06
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            11/07
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            busbud logoThe cheapest trip from Columbia, MO to Knoxville, TN was searched and found on Nov 1, 2025 with a price of $59

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbia, MO to Knoxville, TN, as early as possible.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while traveling from Columbia to Knoxville.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Columbia to Knoxville.

            Buses are energy-efficient. Carrying a passenger over 100 kms by bus only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Columbia to Knoxville.

            Tune out to the fine sounds of your best music playlist on your bus trip from Columbia to Knoxville while indulging in miles on end of beautiful scenic views.

            Did you know?

            The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

            The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            Will you be returning to Columbia, MO by bus?

            Bus from Knoxville, TN to Columbia, MO

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