Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | WJW Investments Bus Stop | Knoxville Bus Station | CheapestFastest |
Last refresh of the prices: Yesterday at 11:29 AM EST.
Get from Lexington to Knoxville
The journey takes about 3 hours 45 minutes and with fares starting at just $42, it presents an excellent value for a comfortable ride.
Where are the popular stops in Lexington and Knoxville?
Stops in Lexington
- A477 W New Circle Rd, Lexington, KY 40511
- B1801 Alexandria Dr, Lexington, KY 40504, USA
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Lexington, KY to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Lexington to Knoxville?
The cheapest bus tickets from Lexington to Knoxville start from $42. The average price for this route is around $49. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Lexington to Knoxville?
The average bus trip duration from Lexington to Knoxville is 3h 45m, covering a distance of 147 miles (237 km). The quickest bus can get you there in 3h 45m and is operated by Greyhound.
Which bus companies service the Lexington to Knoxville route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Lexington to Knoxville?
The earliest bus departs from Lexington to Knoxville at 3:10pm. And the latest bus departs at 3:10pm.
What are the CO₂ emissions for the bus trip from Lexington to Knoxville?
A bus trip from Lexington to Knoxville generates an estimated 6 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Lexington, KY to Knoxville, TN was searched and found on Nov 30, 2025 with a price of $43To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Lexington, KY to Knoxville, TN, as early as possible.
You can expect to pay from $43 to $64 for a bus ticket from Lexington, KY to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $43 which is on 2025-11-30.
Top traveled bus routes
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