Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Lines, Inc. Chicago Knoxville recent customer reviews
This company should be sued. Worst service I have ever had. Staff was horrible, buses should be decommissioned for being unfit to transport people. Broken down, filthy ,and unsafe . Stations are an embarrasment. Horrible horrible horrible. Rest assured I will never travel by Grehound again.
1 out of 5 stars
Ross R.
customer service agents don't speak english well and are very rude
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Chicago to Knoxville, TN by bus
What is the distance between Chicago and Knoxville?
About 454 miles (731 km) separate Chicago and Knoxville.
What are the departure and arrival stations when taking the bus from Chicago to Knoxville?
If you're headed to Knoxville from Chicago, chances are that your bus will leave from Downtown Greyhound Station and arrive at 100 Kirkwood St. These are the primary departure and arrival locations on this route, but you can also find other options that could better fit your plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/21
$166
11/22
$153
Today
$199
11/24
$154
11/25
$232
11/26
$129
11/27
$123
11/28
$123
The cheapest trip from Chicago to Knoxville, TN was searched and found on Nov 27, 2025 with a price of $123
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Knoxville, TN, as early as possible.
You can expect to pay from $123 to $263 for a bus ticket from Chicago to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $123 which is on 2025-11-27.
The cheapest trip from Chicago to Knoxville, TN was searched and found on Nov 27, 2025 with a price of $123
