Bus from Chicago to Knoxville, TN: Tickets & Schedules

Previously seen trips

Next departures for Chicago to Knoxville on November 26
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
GreyhoundBus
Downtown Greyhound Station
Knoxville Bus StationNo tags
GreyhoundBus
Downtown Greyhound Station
Knoxville Bus StationNo tags
GreyhoundBus
Downtown Greyhound Station
Knoxville Bus StationNo tags
Greyhound + FlixBus
Bus
Chicago 95Th & Dan Ryan
Knoxville Bus StationNo tags
FlixBus + Greyhound
Bus
Chicago 95Th & Dan Ryan
Knoxville Bus StationNo tags

Get from Chicago to Knoxville

This route is served by bus only

The journey takes about 20 hours 51 minutes, and with fares starting at just $139, it presents an excellent value for a comfortable ride.

7bus per day
20h 51mAverage Duration
715 kmDistance
18kgCO₂ emissions

Frequently asked questions about travelling from Chicago to Knoxville, TN by bus

  1. What is the distance between Chicago and Knoxville?

    The distance covered from Chicago to Knoxville is 731 km (454 miles).

  2. What are the departure and arrival locations for buses traveling from Chicago to Knoxville?

    Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at 100 Kirkwood St, in Knoxville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11-24
$223
11-25
$356
Today
$186
11-27
$178
11-28
$178
11-29
$240
11-30
$305
12-01
No data
busbud logoThe cheapest trip from Chicago to Knoxville, TN was searched and found on Nov 27, 2025 with a price of $178

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Knoxville, TN, as early as possible.

You can expect to pay from $178 to $476 for a bus ticket from Chicago to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $178 which is on 2025-11-27.

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