What is the distance between Chicago and Knoxville?

The distance covered from Chicago to Knoxville is 731 km (454 miles).

What are the departure and arrival locations for buses traveling from Chicago to Knoxville?

Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at 100 Kirkwood St, in Knoxville.

Bus Chicago to Knoxville from $129 | Refundable Tickets

Previously seen trips

Next departures for Chicago to Knoxville on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	10:10pm	Downtown Greyhound Station	19h 45m	6:55pm	Knoxville Bus Station	No tags
	Bus	10:30pm	Downtown Greyhound Station	23h 10m	10:40pm	Knoxville Bus Station	No tags
	Bus	6:10am	Downtown Greyhound Station	15h 30m	10:40pm	Knoxville Bus Station	No tags
Greyhound + FlixBus	Bus	8:50pm	Chicago 95Th & Dan Ryan	21h 5m	6:55pm	Knoxville Bus Station	No tags
FlixBus + Greyhound	Bus	8:50pm	Chicago 95Th & Dan Ryan	21h 5m	6:55pm	Knoxville Bus Station	No tags

Get from Chicago to Knoxville

This route is served by bus only

The journey takes about 20 hours 51 minutes, and with fares starting at just $139, it presents an excellent value for a comfortable ride.

7bus per day

20h 51mAverage Duration

715 kmDistance

18kgCO₂ emissions

Where are the popular stops in Chicago and Knoxville?

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
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B
Chicago O'Hare International Airport
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C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Stops in Knoxville

A
100 Kirkwood St
Knoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
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Compare bus companies

Greyhound

3.5/587,397 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87397 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $139

Greyhound Lines, Inc. Chicago Knoxville recent customer reviews

This company should be sued. Worst service I have ever had. Staff was horrible, buses should be decommissioned for being unfit to transport people. Broken down, filthy ,and unsafe . Stations are an embarrasment. Horrible horrible horrible. Rest assured I will never travel by Grehound again.

Ross R.

September 2, 2024

customer service agents don't speak english well and are very rude

María De Lourdes O.

December 23, 2019

FlixBus

3.5/511,449 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Chicago to Knoxville, TN by bus

What is the distance between Chicago and Knoxville?
The distance covered from Chicago to Knoxville is 731 km (454 miles).
What are the departure and arrival locations for buses traveling from Chicago to Knoxville?
Buses traveling this route start their trip at Downtown Greyhound Station, in Chicago, and end it at 100 Kirkwood St, in Knoxville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-24

$223

11-25

$356

Today

$186

11-27

$178

11-28

$178

11-29

$240

11-30

$305

12-01

No data

The cheapest trip from Chicago to Knoxville, TN was searched and found on Nov 27, 2025 with a price of $178

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Knoxville, TN, as early as possible.

You can expect to pay from $178 to $476 for a bus ticket from Chicago to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $178 which is on 2025-11-27.