How much is the bus ticket from Greenville to Knoxville?

The cheapest bus tickets from Greenville to Knoxville start from $68. The average price for this route is around $98. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Greenville to Knoxville?

The average bus trip duration from Greenville to Knoxville is 7h 5m, covering a distance of 120 miles (193 km). The quickest bus can get you there in 7h 5m and is operated by Greyhound .

Which bus companies service the Greenville to Knoxville route?

Several major bus companies operate on this route with 1 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from Greenville to Knoxville?

The earliest bus departs from Greenville to Knoxville at 2:45pm. And the latest bus departs at 2:45pm.

What are the CO₂ emissions for the bus trip from Greenville to Knoxville?

A bus trip from Greenville to Knoxville generates an estimated 5 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from Greenville to Knoxville?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87518 reviews.

Which bus company has the best Wi-Fi from Greenville to Knoxville?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from Greenville to Knoxville?

According to Busbud traveler reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from Greenville to Knoxville?

According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus Greenville to Knoxville from $73 | Refundable Tickets

Previously seen trips

Next departures for Greenville to Knoxville on January 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	12:55pm	1116 Woodruff Rd	9h 25m	10:20pm	Knoxville Bus Station	No tags
FlixBus + Greyhound	Bus	12:55pm	1116 Woodruff Rd	9h 25m	10:20pm	Knoxville Bus Station	No tags
Greyhound + FlixBus	Bus	12:55pm	1116 Woodruff Rd	9h 25m	10:20pm	Knoxville Bus Station	No tags
FlixBus + Greyhound	Bus	12:55pm	1116 Woodruff Rd	9h 10m	10:05pm	Knoxville Bus Station	No tags
FlixBus + Greyhound	Bus	12:55pm	1116 Woodruff Rd	9h 10m	10:05pm	Knoxville Bus Station	No tags

Get from Greenville to Knoxville

This route is served by bus only

The journey takes about 7 hours 5 minutes and with fares starting at just $68, it presents an excellent value for a comfortable ride.

1bus per day

7h 5mAverage Duration

120 milesDistance

5kgCO₂ emissions

Where are the popular stops in Greenville and Knoxville?

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Stops in Knoxville

A
100 Kirkwood St
Knoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Visit page

Compare bus companies

Greyhound

3.5/587,518 reviews

Staff3.6

Timeliness2.9

Cleanliness3.4

Wifi2.5

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/512,164 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from Greenville, SC to Knoxville, TN by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Greenville to Knoxville?
The cheapest bus tickets from Greenville to Knoxville start from $68. The average price for this route is around $98. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Knoxville?
The average bus trip duration from Greenville to Knoxville is 7h 5m, covering a distance of 120 miles (193 km). The quickest bus can get you there in 7h 5m and is operated by Greyhound.
Which bus companies service the Greenville to Knoxville route?
Several major bus companies operate on this route with 1 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Greenville to Knoxville?
The earliest bus departs from Greenville to Knoxville at 2:45pm. And the latest bus departs at 2:45pm.
What are the CO₂ emissions for the bus trip from Greenville to Knoxville?
A bus trip from Greenville to Knoxville generates an estimated 5 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Greenville to Knoxville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87518 reviews.
Which bus company has the best Wi-Fi from Greenville to Knoxville?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Greenville to Knoxville?
According to Busbud traveler reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Knoxville?
According to Busbud traveler reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01/28

$117

01/29

No data

Today

$88

01/31

No data

02/01

No data

02/02

No data

02/03

No data

02/04

No data

The cheapest trip from Greenville, SC to Knoxville, TN was searched and found on Jan 30, 2026 with a price of $88

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Knoxville, TN, as early as possible.