Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 1116 Woodruff Rd | Knoxville Bus Station | CheapestFastest |
Last refresh of the prices: Last Monday at 10:54 PM EST.
Get from Greenville to Knoxville
The journey takes about 7 hours 5 minutes, and with fares starting at just $94, it presents an excellent value for a comfortable ride.
Where are the popular stops in Greenville and Knoxville?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
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Frequently asked questions about travelling from Greenville, SC to Knoxville, TN by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Greenville to Knoxville?
The cheapest bus tickets from Greenville to Knoxville start from $94. The average price for this route is around $135. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Knoxville?
The average bus travel time from Greenville to Knoxville is 7h 5m, covering a distance of 193 km. The quickest bus can get you there in 7h 5m and is operated by Greyhound.
Which bus companies service the Greenville to Knoxville route?
What are the earliest and latest departure times for the bus from Greenville to Knoxville?
The earliest bus departs from Greenville to Knoxville at 2:45pm. And the latest bus departs at 2:45pm.
What are the CO₂ emissions for the bus trip from Greenville to Knoxville?
A bus trip from Greenville to Knoxville generates an estimated 5 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Greenville to Knoxville?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which bus company has the best Wi-Fi from Greenville to Knoxville?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Greenville to Knoxville?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Knoxville?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Knoxville, TN was searched and found on Jan 30, 2026 with a price of $122To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Knoxville, TN, as early as possible.
You can expect to pay from $122 to $163 for a bus ticket from Greenville, SC to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $122 which is on 2026-01-30.
