Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Knoxville Bus Station | The Florida Mall | Cheapest | ||||
 | Bus | Knoxville Bus Station | Orlando Bus Station | Fastest |
Last refresh of the prices: Yesterday at 12:56 AM EST.
Get from Knoxville to Orlando
The journey takes about 19 hours 50 minutes and with fares starting at just $64, it presents an excellent value for a comfortable ride.
Where are the popular stops in Knoxville and Orlando?
Stops in Knoxville
- AKnoxville Area Transit Bus Stop, 100 Kirkwood St, Knoxville, TN 37914, USA
Stops in Orlando
- A555 N John Young Pkwy, Orlando, FL 32805
- BRedCoach Station, 1777 McCoy Road, Orlando, FL 32809
- CJet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
- D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830 - E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA - F
Seaworld Hotels
10100 International Drive , Orlando, 32821
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Knoxville, TN to Orlando by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Knoxville to Orlando?
The cheapest bus tickets from Knoxville to Orlando start from $64. The average price for this route is around $122. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Knoxville to Orlando?
The average bus trip duration from Knoxville to Orlando is 19h 50m, covering a distance of 541 miles (872 km). The quickest bus can get you there in 13h 40m and is operated by Greyhound.
Which bus companies service the Knoxville to Orlando route?
Several major train operators operate on this route with 2 trains available per day.
What is the earliest and latest departure time for the bus from Knoxville to Orlando?
The earliest bus departs from Knoxville to Orlando at 6:10pm. And the latest bus departs at 7:05pm.
What are the CO₂ emissions for the bus trip from Knoxville to Orlando?
A bus trip from Knoxville to Orlando generates an estimated 22 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Orlando was searched and found on Dec 5, 2025 with a price of $100To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Orlando, as early as possible.
You can expect to pay from $100 to $258 for a bus ticket from Knoxville, TN to Orlando based on the last 2 days. You can expect to find the cheapest price for the trip at $100 which is on 2025-12-05.
