What is the travel distance from Columbia to Chicago?

About 318 miles (512 km) separate Columbia and Chicago.

What are the departure and arrival stations when taking the bus from Columbia to Chicago?

The majority of buses traveling from Columbia to Chicago start their journey at Midway Truck Plaza Bus Stop and wind up at Downtown Greyhound Station. These are the main departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.

What are the best sights and things to do in Chicago?

Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Lincoln Park Zoo, Shedd Aquarium, The Field Museum, Museum of Contemporary Art and Brookfield Zoo.

Bus Columbia to Chicago from $48 | Refundable Tickets

Next bus departures

Next departures for Columbia to Chicago on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	8:35pm	Midway Truck Plaza Bus Stop	8h 45m	5:20am	Chicago 95Th & Dan Ryan	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	8:35pm	Midway Truck Plaza Bus Stop	9h 10m	5:45am	Downtown Greyhound Station	No tags
	Bus	8:35pm	Midway Truck Plaza Bus Stop	17h 35m	2:10pm	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Columbia Wabash Station	9h 40m	5:45am	Downtown Greyhound Station	No tags
Greyhound Lines, Inc. + FlixBus	Bus	8:05pm	Columbia Wabash Station	9h 15m	5:20am	Chicago 95Th & Dan Ryan	No tags

Last refresh of the prices: Yesterday at 8:59 PM CST.

Get from Columbia to Chicago

This route is served by bus only

The journey takes about 11 hours 35 minutes and with fares starting at just $55, it presents an excellent value for a comfortable ride.

11bus per day

11h 35mAverage Duration

322 milesDistance

13kgCO₂ emissions

Where are the popular stops in Columbia and Chicago?

Stops in Columbia

A
Midway Truck Plaza Bus Stop
6401 Hwy 40 W , Columbia, Missouri 65202
Visit page

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,387 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

Greyhound Columbia Chicago recent customer reviews

I will never rude it again I had to call off work this morning because I had 3 delays on my busses which is very sad

Shekena W.

December 14, 2020

Bus was wery dirty

Magdalena C.

November 19, 2018

I waited at a transfer for 3 hours because nobody could find a driver

Nikole G.

August 27, 2018

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Columbia, MO to Chicago by bus

What is the travel distance from Columbia to Chicago?
What are the departure and arrival stations when taking the bus from Columbia to Chicago?
What are the best sights and things to do in Chicago?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/19

$58

11/20

$120

Today

$134

11/22

$67

11/23

$77

11/24

No data

11/25

No data

11/26

No data

The cheapest trip from Columbia, MO to Chicago was searched and found on Nov 19, 2025 with a price of $58

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbia, MO to Chicago, as early as possible.

You can expect to pay from $58 to $196 for a bus ticket from Columbia, MO to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $67 which is on 2025-11-22.