How far is Greenville from Indianapolis?

About 398 miles (641 km) separate Greenville and Indianapolis.

What are the departure and arrival stations when taking the bus from Greenville to Indianapolis?

Most of the buses traveling from Greenville to Indianapolis leave from Guadalajara Supermarket Bus Stop and arrive at Greyhound Amtrak Station. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

Bus Greenville to Indianapolis from $84 | Refundable Tickets

Next departures

Next departures for Greenville to Indianapolis on November 6
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
FlixBus + Greyhound Lines, Inc.		10:00pm	1116 Woodruff Rd	23h 25m	9:25pm	Downtown Transit Center	Cheapest
FlixBus + Greyhound Lines, Inc.		10:00pm	1116 Woodruff Rd	20h 40m	6:40pm	Indianapolis Bus Station	Fastest

Last refresh of the prices: Yesterday at 8:58 AM EST.

Compare 2 ways to go from Greenville to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 17 hours 40 minutes and with fares starting at just $81, it presents an excellent value for a comfortable ride.

6bus per day

17h 40mAverage Duration

401 milesDistance

16kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$81 - $184	Average Duration17h 40m	CO₂ emissions 16kg CO₂e
Train	Average Price$176 - $1,323	Average Duration1d 2h	CO₂ emissions 58kg CO₂e

Compare bus companies

FlixBus

3.5/511,206 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

Greyhound

3.5/587,354 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Where are the popular stops in Greenville and Indianapolis?

Stops in Greenville

A - Guadalajara Supermarket Bus Stop

B - Greenville Bus Station

Stops in Indianapolis

A - Greyhound Amtrak Station

Frequently asked questions about traveling from Greenville, SC to Indianapolis by bus

How far is Greenville from Indianapolis?
What are the departure and arrival stations when taking the bus from Greenville to Indianapolis?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/04

No data

11/05

$164

Today

$119

11/07

No data

11/08

No data

11/09

No data

11/10

No data

11/11

No data

The cheapest trip from Greenville, SC to Indianapolis was searched and found on Nov 6, 2025 with a price of $119

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis, as early as possible.

What's the cheapest way to go from Greenville, SC to Indianapolis?

The bus is the cheapest travel choice for this destination

Vehicle Type	Travel Time	Avg Price	Daily Departures
Vehicle TypeBus	Travel Time17h 40m	Avg Price$121	Daily Departures6
Vehicle TypeTrain	Travel Time1d 2h	Avg Price$223	Daily Departures1

Top traveled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. Use Busbud to book your trip online, in your own language and currency, wherever you are. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.