Bus Tickets from Greenville, SC to Indianapolis

Next departures

Next departures for Greenville to Indianapolis on November 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    1116 Woodruff Rd
    Downtown Transit CenterCheapest
    FlixBus + Greyhound Lines, Inc.
      1116 Woodruff Rd
      Indianapolis Bus StationFastest

      Last refresh of the prices: Yesterday at 8:58 AM EST.

      Compare 2 ways to go from Greenville to Indianapolis

      We recommend taking the bus

      Among the sustainable travel choices, the bus stands out as the good way to reach Indianapolis. The journey takes about 17 hours 40 minutes and with fares starting at just $81, it presents an excellent value for a comfortable ride.

      6bus per day
      17h 40mAverage Duration
      401 milesDistance
      16kgCO₂ emissions
      Average Price$81 - $184Average Duration17h 40m
      16kg CO₂e
      Average Price$176 - $1,323Average Duration1d 2h
      58kg CO₂e

      Frequently asked questions about traveling from Greenville, SC to Indianapolis by bus

      Find cheapest prices for buses

      Price is for a one-way ticket for one passenger and based on past searches.

      Best price found
      11/04
      No data
      11/05
      $164
      Today
      $119
      11/07
      No data
      11/08
      No data
      11/09
      No data
      11/10
      No data
      11/11
      No data
      busbud logoThe cheapest trip from Greenville, SC to Indianapolis was searched and found on Nov 6, 2025 with a price of $119

      To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis, as early as possible.

      What's the cheapest way to go from Greenville, SC to Indianapolis?

      busbud logoThe bus is the cheapest travel choice for this destination

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