Find coaches from Greenville, SC to Indianapolis

Next bus departures

Next departures from Greenville to Indianapolis on 6 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Downtown Transit CenterCheapest
FlixBus + Greyhound Lines, Inc.
1116 Woodruff Rd
Indianapolis Bus StationFastest

Last refresh of the prices: Yesterday at 8:58 AM EST.

Compare 2 ways to travel from Greenville to Indianapolis

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 17 hours 40 minutes and with fares starting at just R 1 427, it presents an excellent value for a comfortable ride.

6bus per day
17h 40mAverage duration
646 kmDistance
16kgCO₂ emissions
Bus
Average priceR 1 427 - R 3 259Average duration17h 40m
16kg CO₂e
Train
Average priceR 3 116 - R 23 539Average duration1d 2h
58kg CO₂e

Frequently asked questions about travelling from Greenville, SC to Indianapolis by bus

  1. How much does a bus ticket from Greenville to Indianapolis cost?

    The bus ticket price from Greenville to Indianapolis starts at R 1 427. The best way to find cheap bus tickets from Greenville to Indianapolis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

  2. How long is the bus ride from Greenville to Indianapolis?

    The average travel time between Greenville and Indianapolis is around 17h 40m, although the fastest bus will take about 15h 20m. This is the time it takes to travel the 641 km that separates the two cities.

  3. How many daily bus connections are there between Greenville and Indianapolis?

    The number of buses from Greenville to Indianapolis can differ depending on the day of the week. On average, there are 6 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Greenville to Indianapolis by comparing and selecting the bus that fits your travel style and budget on Busbud.

  4. Which bus companies travel from Greenville to Indianapolis?

    When taking the bus from Greenville to Indianapolis, you can travel comfortably and safely with FlixBus, Greyhound.

  5. What are the departure and arrival stations when taking the bus from Greenville to Indianapolis?

    Buses travelling between Greenville and Indianapolis leave from Guadalajara Supermarket Bus Stop or Greenville Bus Station and arrive at Greyhound Amtrak Station.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
04/11
No data
05/11
R 2 918
Today
R 2 117
07/11
No data
08/11
No data
09/11
No data
10/11
No data
11/11
No data
busbud logoThe cheapest trip from Greenville, SC to Indianapolis was searched and found on 06 Nov 2025 with a price of R 2 117

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Indianapolis as early as possible.

What's the cheapest way to go from Greenville, SC to Indianapolis?

busbud logoThe bus is the cheapest travel choice for this destination

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