Bus from Greenville, SC to Chicago: Tickets & Schedules
Next bus departures
Next departures for Greenville to Chicago on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
Chicago 95Th & Dan Ryan
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
Downtown Greyhound Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
Downtown Greyhound Station
No tags
Bus
1116 Woodruff Rd
Chicago 95Th & Dan Ryan
No tags
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
537-517 W. Jackson Blvd
No tags
Next departures for Greenville to Chicago on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
1116 Woodruff Rd
Downtown Greyhound Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
537-517 W. Jackson Blvd
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
Downtown Greyhound Station
No tags
Bus
1116 Woodruff Rd
537-517 W. Jackson Blvd
No tags
Bus
1116 Woodruff Rd
Chicago 95Th & Dan Ryan
No tags
Next departures for Greenville to Chicago on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
1116 Woodruff Rd
Downtown Greyhound Station
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
537-517 W. Jackson Blvd
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
1116 Woodruff Rd
Downtown Greyhound Station
No tags
Bus
1116 Woodruff Rd
537-517 W. Jackson Blvd
No tags
Bus
1116 Woodruff Rd
Chicago 95Th & Dan Ryan
No tags
Last refresh of the prices: Yesterday at 7:22 PM EST.
Compare 2 ways to go from Greenville to Chicago
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Chicago. The journey takes about 21 hours 30 minutes and with fares starting at just $82, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Greenville, SC to Chicago by bus
What is the distance between Greenville and Chicago?
The distance separating Greenville and Chicago is 561 miles (904 km).
What are the departure and arrival stations when taking the bus from Greenville to Chicago?
If you're headed to Chicago from Greenville, chances are that your bus will leave from Guadalajara Supermarket Bus Stop and arrive at Downtown Greyhound Station. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Chicago?
Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Shedd Aquarium, Cloud Gate, Navy Pier, Robie House and Willis Tower (Sears Tower).
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/24
$202
11/25
$230
Today
$202
11/27
$149
11/28
$190
11/29
$201
11/30
$132
12/01
$157
The cheapest trip from Greenville, SC to Chicago was searched and found on Nov 30, 2025 with a price of $132
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Chicago, as early as possible.
You can expect to pay from $132 to $376 for a bus ticket from Greenville, SC to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $132 which is on 2025-11-30.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Greenville, SC to Chicago?
The bus is the cheapest travel choice for this destination
The cheapest trip from Greenville, SC to Chicago was searched and found on Nov 30, 2025 with a price of $132
The bus is the cheapest travel choice for this destination
