Find coaches from Santa Cruz, CL to Santiago, CL

Next departures

Next departures from Santa Cruz to Santiago on 5 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Andimar
    		Terminal de Buses Santa Cruz
    		San Bernardo, Santiago (Cruce Colon)CheapestFastest
    Buses TranSantin
      		Terminal Santa Cruz
      		Terminal SurNo tags
      Andimar
        		Terminal de Buses Santa Cruz
        		San Bernardo, Santiago (Cruce Colon)No tags
        Buses TranSantin
          		Terminal Santa Cruz
          		Terminal SurNo tags
          Andimar
            		Terminal de Buses Santa Cruz
            		San Bernardo, Santiago (Cruce Colon)No tags

            Last refresh of the prices: Today at 1:35 AM -03.

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            Get from Santa Cruz to Santiago

            This route is served by bus only

            The journey takes about 2 hours 44 minutes, and with fares starting at just R 93, it presents an excellent value for a comfortable ride.

            37bus per day
            2h 44mAverage duration
            147 kmDistance
            4kgCO₂ emissions

            Bus Santa Cruz, CL to Santiago, CL: Trip Overview

            Average ticket priceR 133
            Average bus trip duration2h 44m
            Number of daily buses37
            Earliest bus departure05:00
            Distance146 km
            Latest bus departure21:10

            Santa Cruz to Santiago Bus

            Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Santa Cruz to Santiago.

            We make sure you can find a bus service from Santa Cruz to Santiago from the most reliable bus companies operating this trip.

            Whether it is cheap bus tickets or more luxurious buses going to Santiago from Santa Cruz, we help you find what you're looking for based on how much of a budget you have.

            Frequently asked questions on the trip Santa Cruz, CL - Santiago, CL

            1. How much does a bus ticket from Santa Cruz to Santiago cost?

              The bus ticket price from Santa Cruz to Santiago starts at R 93. The best way to find cheap bus tickets from Santa Cruz to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from Santa Cruz to Santiago?

              The average travel time between Santa Cruz and Santiago is around 2h 44m, although the fastest bus will take about 2h. This is the time it takes to travel the 153 km that separates the two cities.

            3. How many daily bus connections are there between Santa Cruz and Santiago?

              The number of buses from Santa Cruz to Santiago can differ depending on the day of the week. On average, there are 37 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santa Cruz to Santiago by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from Santa Cruz to Santiago?

              When taking the bus from Santa Cruz to Santiago, you can travel comfortably and safely with Buses Andimar, buses TranSantin, Buses Jet Sur.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            02/11
            R 156
            03/11
            R 111
            Today
            R 111
            05/11
            R 111
            06/11
            R 111
            07/11
            R 111
            08/11
            R 111
            09/11
            R 125
            busbud logoThe cheapest trip from Santa Cruz, CL to Santiago, CL was searched and found on 05 Nov 2025 with a price of R 111

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Cruz, CL to Santiago, CL as early as possible.

            You can expect to pay from R 111 to R 206 for a bus ticket from Santa Cruz, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at R 111, which is on 2025-11-05.

            Usually Buses Jet Sur, buses TranSantin will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

            About Bus Travel

            Bus Travel Tips

            If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Santa Cruz to Santiago but it'll also be endearing to native speakers who will surely appreciate your effort.

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santa Cruz to Santiago, get comfy and count the stars.

            Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Santa Cruz to Santiago.

            Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Santa Cruz to Santiago.

            Did you know?

            9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

            Will you be returning to Santa Cruz, CL by bus?

            Bus from Santiago, CL to Santa Cruz, CL

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