Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | San Bernardo, Santiago (Cruce Colon) | Terminal de Buses Santa Cruz | CheapestFastest | |||||
 | Terminal Sur | Terminal Santa Cruz | No tags | |||||
 | Terminal Sur | Terminal Santa Cruz | No tags | |||||
| San Bernardo, Santiago (Cruce Colon) | Terminal de Buses Santa Cruz | No tags | |||||
| Terminal Sur | Terminal Santa Cruz | No tags |
Last refresh of the prices: Last Monday at 9:25 PM -03.
Accepted payments
Get from Santiago to Santa Cruz
The journey takes about 2 hours 40 minutes, and with fares starting at just R 69, it presents an excellent value for a comfortable ride.
Bus Santiago, CL to Santa Cruz, CL: Trip Overview
Compare bus companies
Santiago to Santa Cruz Bus
With Busbud, comparing and booking tickets for a bus from Santiago to Santa Cruz is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.
We make sure you can find a bus service from Santiago to Santa Cruz from the most reliable bus companies operating this trip.
From cheap bus tickets to more luxurious buses travelling from Santiago to Santa Cruz, we offer a wide range of bus services to best suit your needs depending on how much your budget is.
Where are the popular stops in Santiago and Santa Cruz?
Frequently asked questions on the trip Santiago, CL - Santa Cruz, CL
How much does a bus ticket from Santiago to Santa Cruz cost?
The bus ticket price from Santiago to Santa Cruz starts at R 69. The best way to find cheap bus tickets from Santiago to Santa Cruz is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Santiago to Santa Cruz?
The average travel time between Santiago and Santa Cruz is around 2h 40m, although the fastest bus will take about 2h 20m. This is the time it takes to travel the 153 km that separates the two cities.
How many daily bus connections are there between Santiago and Santa Cruz?
The number of buses from Santiago to Santa Cruz can differ depending on the day of the week. On average, there are 38 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santiago to Santa Cruz by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Santiago to Santa Cruz?
When taking the bus from Santiago to Santa Cruz, you can travel comfortably and safely with Buses Andimar, buses TranSantin, Buses Jet Sur.
What are the departure and arrival stations when taking the bus from Santiago to Santa Cruz?
Buses travelling between Santiago and Santa Cruz leave from Terminal Sur or San Borja and arrive at Terminal Santa Cruz.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santiago, CL to Santa Cruz, CL was searched and found on 08 Nov 2025 with a price of R 110To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Santa Cruz, CL as early as possible.
You can expect to pay from R 110 to R 195 for a bus ticket from Santiago, CL to Santa Cruz, CL based on the last 2 days. You can expect to find the cheapest price for the trip at R 110, which is on 2025-11-08.
Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Meet and talk to locals at the bus stations while travelling from Santiago to Santa Cruz.There is no better way to get inside travel information while exploring a new city than to go straight to its people.
Start sightseeing the minute your bus leaves the station. If you're on the night bus from Santiago to Santa Cruz, get comfy and count the stars.
Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Santiago to Santa Cruz that are otherwise impossible to come by with a plane.
Tune out to the fine sounds of your best music playlist on your bus trip from Santiago to Santa Cruz while indulging in miles on end of beautiful scenic views.
Did you know?
Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.
Top travelled bus routes
Why choose Busbud?
The Best Way To Book Bus and Train Tickets
Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.
People from around the world trust Busbud
Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Concepción
- Coach Santiago - Puerto Montt
- Bus Santiago - Antofagasta
- Bus from Santiago to La Serena
- Coach Santiago - Temuco
- Bus Santiago - Mendoza
- Bus from Santiago to Neltume
- Coach Santiago - Purranque
- Bus Santiago - Lota
- Bus from Santiago to Ancud
- Coach Santiago - Iquique
- Bus Santiago - Freire
- Bus from Santiago to Taltal
- Coach Santiago - Traiguén
- Bus Santiago - Cherquenco
Buses Going to Santiago
- Bus from Victoria to Santiago
- Coach Concepción - Santiago
- Bus Valdivia - Santiago
- Bus from Castro to Santiago
- Coach Mendoza - Santiago
- Bus Antofagasta - Santiago
- Bus from Curarrehue to Santiago
- Coach Pinto - Santiago
- Bus Lanco - Santiago
- Bus from Melipeuco to Santiago
- Coach Neltume - Santiago
- Bus Queule - Santiago
- Bus from Conaripe to Santiago
- Coach Chimbarongo - Santiago
- Bus Antuco - Santiago
Popular Buses Connecting Santa Cruz
Buses Leaving from Santa Cruz
- Bus from Santa Cruz to Temuco
- Coach Santa Cruz - Valdivia
- Bus Santa Cruz - Rancagua
- Bus from Santa Cruz to Villarrica
- Coach Santa Cruz - Pucon
- Bus Santa Cruz - Puerto Montt
- Bus from Santa Cruz to Chillan
- Coach Santa Cruz - Pichilemu
- Bus Santa Cruz - San Fernando
- Bus from Santa Cruz to Santiago
- Coach Santa Cruz - Puerto Varas