Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | San Bernardo, Santiago (Cruce Colon) | Terminal de Buses Santa Cruz | Cheapest | ||||
| Bus | San Bernardo, Santiago (Cruce Colon) | Terminal de Buses Santa Cruz | Fastest | ||||
 | Bus | Terminal Sur | Terminal Santa Cruz | No tags | ||||
 | Bus | Terminal Sur | Terminal Santa Cruz | No tags | ||||
| Bus | San Bernardo, Santiago (Cruce Colon) | Terminal de Buses Santa Cruz | No tags |
Last refresh of the prices: Yesterday at 2:05 PM -03.
Get from Santiago to Santa Cruz
The journey takes about 2 hours 40 minutes, and with fares starting at just $2, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santiago and Santa Cruz?
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Zapadores
Los Zapadores 608, Recoleta, Región Metropolitana, Chile
Stops in Santa Cruz
- AAv. Rafael Casanova 480, Santa Cruz, VI Región, Chile
Compare bus companies
Frequently asked questions about travelling from Santiago, CL to Santa Cruz, CL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santiago to Santa Cruz?
The cheapest bus tickets from Santiago to Santa Cruz start from $2. The average price for this route is around $11. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santiago to Santa Cruz?
The average bus travel time from Santiago to Santa Cruz is 2h 40m, covering a distance of 147 km. The quickest bus can get you there in 2h 25m and is operated by Buses Andimar.
Which bus companies service the Santiago to Santa Cruz route?
Several major bus companies operate on this route with 37 buses available per day, including services from Buses Andimar, buses TranSantin, Buses Jet Sur, Condor Bus, Pullman Tur.
What are the earliest and latest departure times for the bus from Santiago to Santa Cruz?
The earliest bus departs from Santiago to Santa Cruz at 6:10am. And the latest bus departs at 9:14pm.
What are the CO₂ emissions for the bus trip from Santiago to Santa Cruz?
A bus trip from Santiago to Santa Cruz generates an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Santiago to Santa Cruz?
According to Busbud customers, the highest-rated bus company on this route is Buses Andimar, with an average rating of 4.2 out of 5 stars based on 54 reviews.
Which bus company has the best Wi-Fi from Santiago to Santa Cruz?
Based on Busbud reviews, the bus company Pullman Tur has the highest Wi-Fi rating with a score of 2.9.
Which bus company has the best on-time performance from Santiago to Santa Cruz?
According to Busbud traveller reviews, the most punctual bus company on this route is Buses Andimar, with a punctuality rating of 4.5 out of 5 stars.
Which bus company has the cleanest buses from Santiago to Santa Cruz?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Buses Andimar, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santiago, CL to Santa Cruz, CL was searched and found on Dec 2, 2025 with a price of $2To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santiago, CL to Santa Cruz, CL, as early as possible.
You can expect to pay from $2 to $17 for a bus ticket from Santiago, CL to Santa Cruz, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $2 which is on 2025-12-02.
Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
