Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal de Buses Santa Cruz | San Bernardo, Santiago (Cruce Colon) | Cheapest | ||||
 | Bus | Terminal Santa Cruz | Terminal Sur | Fastest | ||||
 | Bus | Terminal Santa Cruz | Terminal Sur | No tags | ||||
| Bus | Terminal Santa Cruz | Terminal Sur | No tags | ||||
| Bus | Terminal de Buses Santa Cruz | San Bernardo, Santiago (Cruce Colon) | No tags |
Last refresh of the prices: Today at 6:34 AM -03.
Get from Santa Cruz to Santiago
The journey takes about 2 hours 44 minutes and with fares starting at just $7, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Cruz and Santiago?
Stops in Santa Cruz
- AAv. Rafael Casanova 480, Santa Cruz, VI Región, Chile
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Zapadores
Los Zapadores 608, Recoleta, Región Metropolitana, Chile
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Frequently asked questions about traveling from Santa Cruz, CL to Santiago, CL by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Cruz to Santiago?
The cheapest bus tickets from Santa Cruz to Santiago start from $7. The average price for this route is around $8. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Cruz to Santiago?
The average bus trip duration from Santa Cruz to Santiago is 2h 44m, covering a distance of 82 miles (132 km). The quickest bus can get you there in 2h and is operated by Buses Jet Sur.
Which bus companies service the Santa Cruz to Santiago route?
Several major bus companies operate on this route with 40 buses available per day, including services from Buses Andimar, Buses Jet Sur, buses TranSantin.
What is the earliest and latest departure time for the bus from Santa Cruz to Santiago?
The earliest bus departs from Santa Cruz to Santiago at 5:00am. And the latest bus departs at 9:15pm.
What are the CO₂ emissions for the bus trip from Santa Cruz to Santiago?
A bus trip from Santa Cruz to Santiago generates an estimated 3 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Santa Cruz to Santiago?
According to Busbud customers, the highest-rated bus company on this route is Buses Andimar, with an average rating of 4.1 out of 5 stars based on 56 reviews.
Which bus company has the best Wi-Fi from Santa Cruz to Santiago?
Based on reviews on Busbud, the bus company buses TranSantin has the best Wi-Fi rating with a score of 1.7.
Which bus company has the most timely service from Santa Cruz to Santiago?
According to Busbud traveller reviews, the most timely bus company on this route is Buses Andimar, with a punctuality rating of 4.3 out of 5 stars.
Which bus company has the cleanest buses from Santa Cruz to Santiago?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is buses TranSantin, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Cruz, CL to Santiago, CL was searched and found on Jan 7, 2026 with a price of $6To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Cruz, CL to Santiago, CL, as early as possible.
You can expect to pay from $6 to $12 for a bus ticket from Santa Cruz, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $7 which is on 2026-01-10.
Usually Buses Jet Sur, buses TranSantin will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
