Bus from Santa Cruz, CL to Santiago, CL: Tickets & Schedules

Next bus departures

Next departures for Santa Cruz to Santiago on December 1
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
AndimarBus
    		Terminal de Buses Santa Cruz
    		San Bernardo, Santiago (Cruce Colon)Cheapest
    AndimarBus
      		Terminal de Buses Santa Cruz
      		San Bernardo, Santiago (Cruce Colon)Fastest
      Buses Jet SurBus
      		Terminal Santa Cruz
      		Terminal SurNo tags
      Buses TranSantinBus
      		Terminal Santa Cruz
      		Terminal SurNo tags
      AndimarBus
        		Terminal de Buses Santa Cruz
        		San Bernardo, Santiago (Cruce Colon)No tags

        Last refresh of the prices: Last Wednesday at 6:29 PM -03.

        Get from Santa Cruz to Santiago

        This route is served by bus only

        The journey takes about 2 hours 44 minutes, and with fares starting at just $2, it presents an excellent value for a comfortable ride.

        38bus per day
        2h 44mAverage Duration
        147 kmDistance
        4kgCO₂ emissions

        Frequently asked questions about travelling from Santa Cruz, CL to Santiago, CL by bus

        Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

        1. How much is the bus ticket from Santa Cruz to Santiago?

          The cheapest bus tickets from Santa Cruz to Santiago start from $2. The average price for this route is around $10. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

        2. How long is the bus ride from Santa Cruz to Santiago?

          The average bus travel time from Santa Cruz to Santiago is 2h 44m, covering a distance of 147 km. The quickest bus can get you there in 2h and is operated by Buses Jet Sur.

        3. Which bus companies service the Santa Cruz to Santiago route?

          Several major bus companies operate on this route with 38 buses available per day, including services from Buses Andimar, buses TranSantin, Buses Jet Sur.

        4. What are the earliest and latest departure times for the bus from Santa Cruz to Santiago?

          The earliest bus departs from Santa Cruz to Santiago at 5:00am. And the latest bus departs at 9:10pm.

        5. What are the CO₂ emissions for the bus trip from Santa Cruz to Santiago?

          A bus trip from Santa Cruz to Santiago generates an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

        6. What is the best bus company from Santa Cruz to Santiago?

          According to Busbud customers, the highest-rated bus company on this route is Buses Andimar, with an average rating of 4.2 out of 5 stars based on 54 reviews.

        7. Which bus company has the best Wi-Fi from Santa Cruz to Santiago?

          Based on Busbud reviews, the bus company buses TranSantin has the highest Wi-Fi rating with a score of 1.7.

        8. Which bus company has the best on-time performance from Santa Cruz to Santiago?

          According to Busbud traveller reviews, the most punctual bus company on this route is Buses Andimar, with a punctuality rating of 4.5 out of 5 stars.

        9. Which bus company has the cleanest buses from Santa Cruz to Santiago?

          According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Buses Andimar, with a cleanliness rating of 4.5 out of 5 stars.

        Find cheapest prices for buses

        Price is for a one-way ticket for one passenger and based on past searches.

        Best price found
        11-26
        $2
        11-27
        $2
        Today
        $2
        11-29
        $2
        11-30
        $10
        12-01
        $2
        12-02
        $2
        12-03
        $2
        busbud logoThe cheapest trip from Santa Cruz, CL to Santiago, CL was searched and found on Nov 26, 2025 with a price of $2

        To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Cruz, CL to Santiago, CL, as early as possible.

        You can expect to pay from $2 to $16 for a bus ticket from Santa Cruz, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at $2 which is on 2025-11-29.

        Usually Buses Jet Sur will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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