Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Knoxville Bus Station | Spartanburg | No tags | ||||
| Bus | Knoxville Bus Station | Spartanburg | No tags | ||||
| Bus | Knoxville Bus Station | Spartanburg | No tags | ||||
| Bus | Knoxville Bus Station | Spartanburg | No tags | ||||
| Bus | Knoxville Bus Station | Spartanburg | No tags |
Get from Knoxville to Spartanburg
The journey takes about 8 hours 10 minutes and with fares starting at just $95, it presents an excellent value for a comfortable ride.
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Where are the popular stops in Knoxville and Spartanburg?
Frequently asked questions about traveling from Knoxville, TN to Spartanburg by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Knoxville, TN to Spartanburg was searched and found on Nov 10, 2025 with a price of $107To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Knoxville, TN to Spartanburg, as early as possible.
Top traveled bus routes
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Popular Buses Connecting Knoxville
Buses Leaving from Knoxville
- Bus from Knoxville to Charlotte
- Bus Knoxville - Marathon
- Knoxville - Lexington
- Bus from Knoxville to Chicago
- Bus Knoxville - Orlando
- Knoxville - Greenville
- Bus from Knoxville to Nashville
- Bus Knoxville - Atlanta
- Knoxville - New York City
- Bus from Knoxville to Memphis
- Bus Knoxville - Washington
- Knoxville - Miami
- Bus from Knoxville to Tampa
- Bus Knoxville - Jackson
- Knoxville - Cleveland
Buses Going to Knoxville
- Bus from Nashville to Knoxville
- Bus Memphis - Knoxville
- Charlotte - Knoxville
- Bus from Chicago to Knoxville
- Bus Tampa - Knoxville
- Detroit - Knoxville
- Bus from Atlanta to Knoxville
- Bus Hartford - Knoxville
- New York City - Knoxville
- Bus from Louisville to Knoxville
- Bus Cincinnati - Knoxville
- Lexington - Knoxville
- Bus from Dallas to Knoxville
- Bus Greenville - Knoxville
- Orlando - Knoxville
Popular Buses Connecting Spartanburg
Buses Leaving from Spartanburg
- Bus from Spartanburg to Greenville
- Bus Spartanburg - Greenville
- Spartanburg - Charlotte
- Bus from Spartanburg to Atlanta
- Bus Spartanburg - Knoxville
- Spartanburg - Charleston
- Bus from Spartanburg to Myrtle Beach
- Bus Spartanburg - Raleigh
- Spartanburg - New York City
- Bus from Spartanburg to Charleston
- Bus Spartanburg - Grand Rapids
- Spartanburg - Miami
- Bus from Spartanburg to Orlando
- Bus Spartanburg - Newark
- Spartanburg - Gastonia
Buses Going to Spartanburg
- Bus from Greenville to Spartanburg
- Bus Greenville - Spartanburg
- El Paso - Spartanburg
- Bus from Burlington to Spartanburg
- Bus Orlando - Spartanburg
- Asheville - Spartanburg
- Bus from Atlanta to Spartanburg
- Bus Charlotte - Spartanburg
- Holland - Spartanburg
- Bus from Elyria to Spartanburg
- Bus New York City - Spartanburg
- Charleston - Spartanburg
- Bus from Winston-Salem to Spartanburg
- Bus Myrtle Beach - Spartanburg
- Philadelphia - Spartanburg
Popular routes in this country
- Bus from Fort Lauderdale to Orlando
- Bus Dallas - Houston
- Albany - New York City
- Bus from Las Vegas to Los Angeles
- Bus Tampa - Miami
- Austin - Dallas
- Bus from Dallas to Austin
- Bus Miami - Tampa
- Austin - Houston
- Bus from Houston to San Antonio
- Bus Seattle - Leavenworth
- Houston - Austin
- Bus from San Antonio to Houston
- Bus Atlanta - Orlando
- Dallas - San Antonio