Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Bus Station | Spartanburg | CheapestFastest |
Last refresh of the prices: Today at 3:33 AM EST.
Get from Myrtle Beach to Spartanburg
The journey takes about 16 hours 20 minutes and with fares starting at just $60, it presents an excellent value for a comfortable ride.
Where are the popular stops in Myrtle Beach and Spartanburg?
Stops in Spartanburg
- A9133 Fairforest Rd. Spartanburg, SC , C.P. 29301
- B
Spartanburg Bus Stop
1402 E Main St, Spartanburg, SC 29307, USA - C
Sparta Passenger Center
100 Liberty St, Spartanburg, SC 29306, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Myrtle Beach to Spartanburg by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Myrtle Beach to Spartanburg?
The cheapest bus tickets from Myrtle Beach to Spartanburg start from $60. The average price for this route is around $60. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Myrtle Beach to Spartanburg?
The average bus trip duration from Myrtle Beach to Spartanburg is 16h 20m, covering a distance of 200 miles (322 km). The quickest bus can get you there in 16h 20m and is operated by Greyhound.
Which bus companies service the Myrtle Beach to Spartanburg route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Myrtle Beach to Spartanburg?
The earliest bus departs from Myrtle Beach to Spartanburg at 12:45pm. And the latest bus departs at 1:55pm.
What are the CO₂ emissions for the bus trip from Myrtle Beach to Spartanburg?
A bus trip from Myrtle Beach to Spartanburg generates an estimated 8 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Myrtle Beach to Spartanburg was searched and found on Nov 30, 2025 with a price of $184To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Myrtle Beach to Spartanburg, as early as possible.
You can expect to pay from $184 to $184 for a bus ticket from Myrtle Beach to Spartanburg based on the last 2 days. You can expect to find the cheapest price for the trip at $184 which is on 2025-11-30.
Top traveled bus routes
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Popular bus departures from Myrtle Beach
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