How far is Harrisburg from Greenville?

Harrisburg and Greenville are 481 miles (775 km) apart.

What are the departure and arrival stations when taking the bus from Harrisburg to Greenville?

Most of the buses traveling from Harrisburg to Greenville leave from Harrisburg Bieber Greyhound Station and arrive at Guadalajara Supermarket Bus Stop. These are the primary departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.

Bus Harrisburg to Greenville from $214 | Refundable Tickets

Previously seen trips

Next departures for Harrisburg to Greenville on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	2:30pm	Harrisburg Bus Station	20h 35m	11:05am	1116 Woodruff Rd	No tags
FlixBus + Greyhound	Bus	3:05am	Harrisburg Bus Station	16h 25m	7:30pm	1116 Woodruff Rd	No tags
FlixBus + Greyhound	Bus	10:20am	Harrisburg Bus Station	21h 55m	8:15am	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	2:30pm	Harrisburg Bus Station	20h 15m	10:45am	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	9:05pm	Harrisburg Bus Station	22h 25m	7:30pm	1116 Woodruff Rd	No tags

Compare 2 ways to go from Harrisburg to Greenville

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Greenville. The journey takes about 16 hours 19 minutes and with fares starting at just $165, it presents an excellent value for a comfortable ride.

1train per day

16h 19mAverage Duration

480 milesDistance

70kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$70 - $371	Average Duration22h 45m	CO₂ emissions 19kg CO₂e
Train	Average Price$165 - $677	Average Duration16h 19m	CO₂ emissions 70kg CO₂e

Where are the popular stops in Harrisburg and Greenville?

Stops in Harrisburg

A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Compare bus companies

Greyhound

3.5/587,397 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,449 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about traveling from Harrisburg to Greenville, SC by bus

How far is Harrisburg from Greenville?
What are the departure and arrival stations when taking the bus from Harrisburg to Greenville?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/24

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11/25

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Today

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11/27

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11/28

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11/29

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11/30

$214

12/01

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The cheapest trip from Harrisburg to Greenville, SC was searched and found on Nov 30, 2025 with a price of $214

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Greenville, SC, as early as possible.

You can expect to pay from $214 to $214 for a bus ticket from Harrisburg to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $214 which is on 2025-11-30.