How far is Harrisburg from Greenville?

The distance between Harrisburg and Greenville is approximately 775 km (481 miles).

What are the departure and arrival locations for buses traveling from Harrisburg to Greenville?

Buses departing from Harrisburg Bieber Greyhound Station in Harrisburg will take you to Guadalajara Supermarket Bus Stop in Greenville.

Bus Harrisburg to Greenville from $309 | Refundable Tickets

Previously seen trips

Next departures for Harrisburg to Greenville on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound + FlixBus	Bus	2:30pm	Harrisburg Bus Station	20h 35m	11:05am	1116 Woodruff Rd	No tags
FlixBus + Greyhound	Bus	3:05am	Harrisburg Bus Station	16h 25m	7:30pm	1116 Woodruff Rd	No tags
FlixBus + Greyhound	Bus	10:20am	Harrisburg Bus Station	21h 55m	8:15am	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	2:30pm	Harrisburg Bus Station	20h 15m	10:45am	1116 Woodruff Rd	No tags
Greyhound + FlixBus	Bus	9:05pm	Harrisburg Bus Station	22h 25m	7:30pm	1116 Woodruff Rd	No tags

Compare 2 ways to go from Harrisburg to Greenville

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Greenville. The journey takes about 16 hours 19 minutes, and with fares starting at just $238, it presents an excellent value for a comfortable ride.

1train per day

16h 19mAverage Duration

774 kmDistance

70kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$101 - $535	Average Duration22h 45m	CO₂ emissions 19kg CO₂e
Train	Average Price$238 - $977	Average Duration16h 19m	CO₂ emissions 70kg CO₂e

Where are the popular stops in Harrisburg and Greenville?

Stops in Harrisburg

A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101

Stops in Greenville

A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611
B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607

Compare bus companies

Greyhound

3.5/587,397 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,449 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Harrisburg to Greenville, SC by bus

How far is Harrisburg from Greenville?
The distance between Harrisburg and Greenville is approximately 775 km (481 miles).
What are the departure and arrival locations for buses traveling from Harrisburg to Greenville?
Buses departing from Harrisburg Bieber Greyhound Station in Harrisburg will take you to Guadalajara Supermarket Bus Stop in Greenville.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-24

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11-25

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Today

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11-27

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11-28

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11-29

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11-30

$309

12-01

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The cheapest trip from Harrisburg to Greenville, SC was searched and found on Nov 30, 2025 with a price of $309

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Greenville, SC, as early as possible.

You can expect to pay from $309 to $309 for a bus ticket from Harrisburg to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $309 which is on 2025-11-30.