Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | UC Irvine (Crawford Hall) | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | UC Irvine (Crawford Hall) | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Anaheim Regional Transportation Intermodal Center | No tags | ||||
 | Bus | 537-517 W. Jackson Blvd | Anaheim Regional Transportation Intermodal Center | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Santa Ana Bus Station | No tags |
Last refresh of the prices: Today at 12:23 PM CST.
Get from Chicago to Santa Ana
The journey takes about 2 days, 4 hours 40 minutes and with fares starting at just $206, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and Santa Ana?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Chicago to Santa Ana, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Santa Ana?
The cheapest bus tickets from Chicago to Santa Ana start from $206. The average price for this route is around $394. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Santa Ana?
The average bus trip duration from Chicago to Santa Ana is 2d 4h, covering a distance of 1727 miles (2785 km). The quickest bus can get you there in 2d 7h and is operated by Greyhound.
Which bus companies service the Chicago to Santa Ana route?
Several major train operators operate on this route with 12 trains available per day.
What is the earliest and latest departure time for the bus from Chicago to Santa Ana?
The earliest bus departs from Chicago to Santa Ana at 12:40am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to Santa Ana?
A bus trip from Chicago to Santa Ana generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Santa Ana, US was searched and found on Jan 20, 2026 with a price of $199To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Santa Ana, US, as early as possible.
You can expect to pay from $199 to $407 for a bus ticket from Chicago to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $407 which is on 2026-01-23.
