Bus Tickets from San Diego, CA, US to Santa Ana, US

Next bus departures

Next departures for San Diego to Santa Ana on November 21
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.Bus
Greyhound Bus Stop
Santa Ana Bus StationCheapest
FlixBusBus
UCSD Health La Jolla Station
UC Irvine (Crawford Hall)Fastest
FlixBusBus
San Diego (Old Town-FlixBus)
Anaheim Regional Transportation Intermodal CenterNo tags
Greyhound Lines, Inc.Bus
Greyhound Bus Stop
Anaheim Regional Transportation Intermodal CenterNo tags
FlixBusBus
San Diego (Old Town-FlixBus)
UC Irvine (Crawford Hall)No tags

Last refresh of the prices: Last Tuesday at 7:21 PM PST.

Get from San Diego to Santa Ana

This route is served by bus only

The journey takes about 2 hours and with fares starting at just $21, it presents an excellent value for a comfortable ride.

18bus per day
2hAverage Duration
79 milesDistance
3kgCO₂ emissions

Frequently asked questions about traveling from San Diego, CA, US to Santa Ana, US by bus

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/18
$19
11/19
$18
Today
$17
11/21
$21
11/22
$20
11/23
$21
11/24
$21
11/25
$22
busbud logoThe cheapest trip from San Diego, CA, US to Santa Ana, US was searched and found on Nov 20, 2025 with a price of $17

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Ana, US, as early as possible.

You can expect to pay from $17 to $42 for a bus ticket from San Diego, CA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $20 which is on 2025-11-22.

Usually Greyhound, FlixBus, Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

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