Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | San Diego (Old Town-FlixBus) | Anaheim Regional Transportation Intermodal Center | Cheapest | ||||
| Bus | UCSD Health La Jolla Station | UC Irvine (Crawford Hall) | Fastest | ||||
| Bus | San Diego (Old Town-FlixBus) | UC Irvine (Crawford Hall) | No tags | ||||
 | Bus | Greyhound Bus Stop | Anaheim Regional Transportation Intermodal Center | No tags | ||||
 | Bus | Cross Border Xpress CBX (USA) | Santa Ana E Santa Ana Blvd | No tags |
Last refresh of the prices: Yesterday at 22:08 PST.
Get from San Diego to Santa Ana
The journey takes about 2 hours 5 minutes, and with fares starting at just £16, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Diego and Santa Ana?
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
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Frequently asked questions about travelling by bus from San Diego, CA, US to Santa Ana, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from San Diego to Santa Ana?
The cheapest coach tickets from San Diego to Santa Ana start from £16. The average price for this route is around £35. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from San Diego to Santa Ana?
The average bus journey time from San Diego to Santa Ana is 2h 5m, covering a distance of 74 miles. The fastest bus can take you there in 1h 15m and is operated by Los Limousines.
Which bus companies service the San Diego to Santa Ana route?
Several major bus companies operate on this route with 18 buses available per day, including services from Los Limousines, FlixBus, Greyhound, Las Vegas Shuttles.
What is the earliest and latest departure time for the bus from San Diego to Santa Ana?
The earliest bus departs from San Diego to Santa Ana at 00:30. And the latest bus departs at 22:30.
What are the CO₂ emissions for the bus trip from San Diego to Santa Ana?
A bus journey from San Diego to Santa Ana produces an estimated 3 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from San Diego to Santa Ana?
According to Busbud customers, the highest-rated bus company on this route is FlixBus, with an average rating of 3.5 out of 5 stars based on 11380 reviews.
Which company has the best Wi-Fi from San Diego to Santa Ana?
Based on Busbud reviews, the bus company Las Vegas Shuttles has the best Wi-Fi rating with a score of 3.2.
Which bus company offers the most punctual service from San Diego to Santa Ana?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Santa Ana?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Las Vegas Shuttles, with a cleanliness rating of 4.8 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Diego, CA, US to Santa Ana, US was searched and found on 2 Dec 2025 with a price of £14To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Ana, US as early as possible.
You can expect to pay from £14 to £38 for a bus ticket from San Diego, CA, US to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at £14, which is on 2025-12-02.
Usually Los Limousines, FlixBus, Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
