Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Santa Ana E Santa Ana Blvd | San Ysidro Greyhound Bus Station | Cheapest | ||||
| Bus | Santa Ana E Santa Ana Blvd | San Ysidro Greyhound Bus Station | Fastest | ||||
 | Bus | Anaheim Regional Transportation Intermodal Center | San Ysidro Bus terminal | No tags | ||||
 | Bus | Santa Ana Bus Station | San Ysidro Bus terminal | No tags | ||||
| Bus | Santa Ana E Santa Ana Blvd | San Ysidro Greyhound Bus Station | No tags |
Last refresh of the prices: Today at 4:42 AM PST.
Get from Santa Ana to San Ysidro
The journey takes about 3 hours and with fares starting at just $24, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Ana and San Ysidro?
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
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Frequently asked questions about traveling from Santa Ana, US to San Ysidro, CA by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Ana to San Ysidro?
The cheapest bus tickets from Santa Ana to San Ysidro start from $24. The average price for this route is around $45. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Ana to San Ysidro?
The average bus trip duration from Santa Ana to San Ysidro is 3h, covering a distance of 96 miles (155 km). The quickest bus can get you there in 1h 45m and is operated by Los Limousines.
Which bus companies service the Santa Ana to San Ysidro route?
Several major bus companies operate on this route with 20 buses available per day, including services from Los Limousines, Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from Santa Ana to San Ysidro?
The earliest bus departs from Santa Ana to San Ysidro at 5:55am. And the latest bus departs at 10:45pm.
What are the CO₂ emissions for the bus trip from Santa Ana to San Ysidro?
A bus trip from Santa Ana to San Ysidro generates an estimated 4 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Santa Ana to San Ysidro?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Santa Ana to San Ysidro?
Based on reviews on Busbud, the bus company Los Limousines has the best Wi-Fi rating with a score of 2.8.
Which bus company has the most timely service from Santa Ana to San Ysidro?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Santa Ana to San Ysidro?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, US to San Ysidro, CA was searched and found on Dec 2, 2025 with a price of $19To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Ysidro, CA, as early as possible.
You can expect to pay from $19 to $61 for a bus ticket from Santa Ana, US to San Ysidro, CA based on the last 2 days. You can expect to find the cheapest price for the trip at $19 which is on 2025-12-02.
Usually Los Limousines will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
