Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Anaheim Regional Transportation Intermodal Center | San Francisco Bus Station | CheapestFastest | ||||
| Bus | Santa Ana Bus Station | San Francisco Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | UC Irvine (Crawford Hall) | San Francisco Bus Station | No tags |
Last refresh of the prices: Last Monday at 8:13 PM PST.
Get from Santa Ana to San Francisco
The journey takes about 12 hours 35 minutes and with fares starting at just $58, it presents an excellent value for a comfortable ride.
Where are the popular stops in Santa Ana and San Francisco?
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
Stops in San Francisco
- A
Hyde/Beach (Fisherman's Wharf)
700 Beach Street, San Francisco, CA 94109, USA - B
Powell Station
25 Cyril Magnin St , San Francisco, CA 94102-2812 - C
Union Square Hilton
255 Mason St,, San Francisco, CA 94102-2114 - D
San Francisco Greyhound Station
200 Folsom St, San Francisco, CA 94105 - E
444 Townsend St.
444 Townsend St, San Francisco, CA 94107, USA
Compare bus companies
Frequently asked questions about traveling from Santa Ana, US to San Francisco, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Ana to San Francisco?
The cheapest bus tickets from Santa Ana to San Francisco start from $58. The average price for this route is around $161. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Ana to San Francisco?
The average bus trip duration from Santa Ana to San Francisco is 12h 35m, covering a distance of 373 miles (601 km). The quickest bus can get you there in 8h 35m and is operated by Greyhound.
Which bus companies service the Santa Ana to San Francisco route?
What is the earliest and latest departure time for the bus from Santa Ana to San Francisco?
The earliest bus departs from Santa Ana to San Francisco at 8:15am. And the latest bus departs at 9:40pm.
What are the CO₂ emissions for the bus trip from Santa Ana to San Francisco?
A bus trip from Santa Ana to San Francisco generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from Santa Ana to San Francisco?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Santa Ana to San Francisco?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from Santa Ana to San Francisco?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Santa Ana to San Francisco?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, US to San Francisco, US was searched and found on Nov 27, 2025 with a price of $144To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, US to San Francisco, US, as early as possible.
You can expect to pay from $144 to $199 for a bus ticket from Santa Ana, US to San Francisco, US based on the last 2 days. You can expect to find the cheapest price for the trip at $185 which is on 2025-11-30.
