Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | UC Irvine (Crawford Hall) | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | UC Irvine (Crawford Hall) | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Anaheim Regional Transportation Intermodal Center | No tags | ||||
 | Bus | 537-517 W. Jackson Blvd | Anaheim Regional Transportation Intermodal Center | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | Santa Ana Bus Station | No tags |
Last refresh of the prices: Today at 12:23 PM CST.
Get from Chicago to Santa Ana
The journey takes about 2 days, 4 hours 40 minutes, and with fares starting at just $291, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and Santa Ana?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in Santa Ana
- A
Santa Ana Greyhound Bus Station
1000 E Santa Ana Blvd, Santa Ana, CA 92701 - B
602 S Main St
602 S Main St, Santa Ana, CA 92701, USA
Compare bus companies
Based on 87516 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $291
Frequently asked questions about travelling from Chicago to Santa Ana, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to Santa Ana?
The cheapest bus tickets from Chicago to Santa Ana start from $291. The average price for this route is around $556. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to Santa Ana?
The average bus travel time from Chicago to Santa Ana is 2d 4h, covering a distance of 2785 km. The quickest bus can get you there in 2d 7h and is operated by Greyhound.
Which bus companies service the Chicago to Santa Ana route?
Several major bus companies operate on this route with 12 buses available per day.
What are the earliest and latest departure times for the bus from Chicago to Santa Ana?
The earliest bus departs from Chicago to Santa Ana at 12:40am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to Santa Ana?
A bus trip from Chicago to Santa Ana generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to Santa Ana, US was searched and found on Jan 20, 2026 with a price of $281To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Santa Ana, US, as early as possible.
You can expect to pay from $281 to $575 for a bus ticket from Chicago to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at $575 which is on 2026-01-23.
