Find coaches from Chicago to Santa Ana, US

Next departures

Next departures from Chicago to Santa Ana on 7 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		Chicago 95Th & Dan Ryan
    		UC Irvine (Crawford Hall)Cheapest
    Greyhound Lines, Inc.
      		Downtown Greyhound Station
      		Santa Ana Bus StationFastest
      FlixBus + Greyhound Lines, Inc.
        		Chicago 95Th & Dan Ryan
        		Anaheim Regional Transportation Intermodal CenterNo tags
        Greyhound Lines, Inc.
          		Downtown Greyhound Station
          		Anaheim Regional Transportation Intermodal CenterNo tags
          FlixBus + Greyhound Lines, Inc.
            		Chicago 95Th & Dan Ryan
            		Anaheim Regional Transportation Intermodal CenterNo tags

            Last refresh of the prices: Today at 2:56 PM CST.

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            Get from Chicago to Santa Ana

            This route is served by bus only

            The journey takes about 2 days, 5 hours, and with fares starting at just R 3 180, it presents an excellent value for a comfortable ride.

            16bus per day
            2d 5hAverage duration
            2792 kmDistance
            70kgCO₂ emissions

            Bus Chicago to Santa Ana, US: Trip Overview

            Average ticket priceR 5 858
            Average bus trip duration2d 5h
            Number of daily buses16
            Earliest bus departure10:00
            Distance2791 km
            Latest bus departure23:50

            Chicago to Santa Ana Bus

            Busbud helps you find a bus from Chicago to Santa Ana. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            Bus service from Chicago to Santa Ana will be provided by the most trusted bus companies.

            Discover how much the bus trip from Chicago to Santa Ana will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip Chicago - Santa Ana, US

            1. How much does a bus ticket from Chicago to Santa Ana cost?

              The bus ticket price from Chicago to Santa Ana starts at R 3 180. The best way to find cheap bus tickets from Chicago to Santa Ana is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from Chicago to Santa Ana?

              The average travel time between Chicago and Santa Ana is around 2d 5h, although the fastest bus will take about 2d 2h. This is the time it takes to travel the 2790 km that separates the two cities.

            3. How many daily bus connections are there between Chicago and Santa Ana?

              The number of buses from Chicago to Santa Ana can differ depending on the day of the week. On average, there are 16 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Chicago to Santa Ana by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from Chicago to Santa Ana?

              When taking the bus from Chicago to Santa Ana, you can travel comfortably and safely with Greyhound.

            5. What are the departure and arrival stations when taking the bus from Chicago to Santa Ana?

              Buses travelling between Chicago and Santa Ana leave from Downtown Greyhound Station or Chicago O'Hare International Airport and arrive at Santa Ana Greyhound Bus Station, 602 S Main St.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            03/11
            R 5 248
            04/11
            R 5 569
            Today
            R 2 927
            06/11
            No data
            07/11
            R 4 998
            08/11
            No data
            09/11
            No data
            10/11
            No data
            busbud logoThe cheapest trip from Chicago to Santa Ana, US was searched and found on 05 Nov 2025 with a price of R 2 927

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Santa Ana, US as early as possible.

            You can expect to pay from R 2 927 to R 6 667 for a bus ticket from Chicago to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 4 998, which is on 2025-11-07.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Santa Ana!

            Much more than a mere vehicle taking you from Chicago to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

            Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Chicago to Santa Ana will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

            Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Santa Ana.

            Did you know?

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

            Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

            Will you be returning to Chicago by bus?

            Bus from Santa Ana, US to Chicago

            Why choose Busbud?

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