- Chicago to Santa Ana buses
Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Chicago 95Th & Dan Ryan | UC Irvine (Crawford Hall) | Cheapest | |||||
![]() | Downtown Greyhound Station | Santa Ana Bus Station | Fastest | |||||
FlixBus + Greyhound Lines, Inc. | Chicago 95Th & Dan Ryan | Anaheim Regional Transportation Intermodal Center | No tags | |||||
![]() | Downtown Greyhound Station | Anaheim Regional Transportation Intermodal Center | No tags | |||||
FlixBus + Greyhound Lines, Inc. | Chicago 95Th & Dan Ryan | Anaheim Regional Transportation Intermodal Center | No tags |
Last refresh of the prices: Today at 2:56 PM CST.
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Get from Chicago to Santa Ana
The journey takes about 2 days, 5 hours, and with fares starting at just R 3 180, it presents an excellent value for a comfortable ride.
Bus Chicago to Santa Ana, US: Trip Overview
Compare bus companies
Based on 87353 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the Wi-Fi. Greyhound ticket prices on this trip start at R 3 180
Chicago to Santa Ana Bus
Busbud helps you find a bus from Chicago to Santa Ana. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
Bus service from Chicago to Santa Ana will be provided by the most trusted bus companies.
Discover how much the bus trip from Chicago to Santa Ana will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.
Where are the popular stops in Chicago and Santa Ana?
Frequently asked questions on the trip Chicago - Santa Ana, US
How much does a bus ticket from Chicago to Santa Ana cost?
The bus ticket price from Chicago to Santa Ana starts at R 3 180. The best way to find cheap bus tickets from Chicago to Santa Ana is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Chicago to Santa Ana?
The average travel time between Chicago and Santa Ana is around 2d 5h, although the fastest bus will take about 2d 2h. This is the time it takes to travel the 2790 km that separates the two cities.
How many daily bus connections are there between Chicago and Santa Ana?
The number of buses from Chicago to Santa Ana can differ depending on the day of the week. On average, there are 16 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Chicago to Santa Ana by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Chicago to Santa Ana?
When taking the bus from Chicago to Santa Ana, you can travel comfortably and safely with Greyhound.
What are the departure and arrival stations when taking the bus from Chicago to Santa Ana?
Buses travelling between Chicago and Santa Ana leave from Downtown Greyhound Station or Chicago O'Hare International Airport and arrive at Santa Ana Greyhound Bus Station, 602 S Main St.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Santa Ana, US as early as possible.
You can expect to pay from R 2 927 to R 6 667 for a bus ticket from Chicago to Santa Ana, US based on the last 2 days. You can expect to find the cheapest price for the trip at R 4 998, which is on 2025-11-07.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Chicago and Santa Ana!
Much more than a mere vehicle taking you from Chicago to Santa Ana, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Chicago to Santa Ana will emit half the CO2 emitted by a train, and radically less than a car or an airplane.
Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Chicago to Santa Ana.
Did you know?
Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
Top travelled bus routes
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Popular Buses Connecting Chicago
Buses Leaving from Chicago
- Bus from Chicago to Columbia
- Coach Chicago - Toronto
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- Coach Chicago - Washington
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- Coach Chicago - Salisbury
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Buses Going to Chicago
- Bus from Boston to Chicago
- Coach Toronto - Chicago
- Bus Atlanta - Chicago
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- Coach Bridgeport - Chicago
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- Bus from Springfield to Chicago
- Coach Wilmington - Chicago
- Bus Danville - Chicago
- Bus from Kankakee to Chicago
- Coach Laurinburg - Chicago
- Bus Fayetteville - Chicago
- Bus from Syracuse to Chicago
- Coach Rantoul - Chicago
- Bus Hope - Chicago
Popular Buses Connecting Santa Ana
Buses Leaving from Santa Ana
- Bus from Santa Ana to Las Vegas
- Coach Santa Ana - Long Beach
- Bus Santa Ana - Los Angeles
- Bus from Santa Ana to Guadalajara
- Coach Santa Ana - Chihuahua
- Bus Santa Ana - Hermosillo
- Bus from Santa Ana to Indio
- Coach Santa Ana - Chicago
- Bus Santa Ana - Temecula
- Bus from Santa Ana to Tulare
- Coach Santa Ana - Goshen
- Bus Santa Ana - Conroe
- Bus from Santa Ana to Lawton
- Coach Santa Ana - Visalia
- Bus Santa Ana - Bellingham
Buses Going to Santa Ana
- Bus from Pueblo to Santa Ana
- Coach San Jose - Santa Ana
- Bus Anaheim - Santa Ana
- Bus from Long Beach to Santa Ana
- Coach Chicago - Santa Ana
- Bus Boston - Santa Ana
- Bus from Portland to Santa Ana
- Coach Albuquerque - Santa Ana
- Bus Bakersfield - Santa Ana
- Bus from Temecula to Santa Ana
- Coach Delano - Santa Ana
- Bus Jacksonville - Santa Ana
- Bus from New York City to Santa Ana
- Coach Salinas - Santa Ana
- Bus East Los Angeles - Santa Ana
Popular routes in this country
- Bus from Buffalo to Niagara Falls
- Coach New York City - Fleischmanns
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- Coach San Diego - Victorville
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- Coach Albany - Ridgewood
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- Coach Albany - New York City
- Bus Boynton Beach - Boston
- Bus from Rancho Cucamonga to Los Angeles
- Coach New York City - Philadelphia
- Bus San Diego - San Francisco






