Next departures for St. Louis to San Antonio on November 19
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + Valley Transit
Bus
Gateway Station
San Antonio Bus Station
CheapestFastest
Next departures for St. Louis to San Antonio on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Gateway Station
San Antonio Bus Station
Cheapest
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Gateway Station
San Antonio Bus Station
Fastest
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Gateway Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Valley Transit
Bus
Gateway Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Gateway Station
Pearl District
No tags
Next departures for St. Louis to San Antonio on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Gateway Station
Pearl District
Cheapest
FlixBus + Greyhound Lines, Inc. + Valley Transit
Bus
Gateway Station
San Antonio Bus Station
Fastest
Greyhound Lines, Inc. + Greyhound Lines Mexico
Bus
Gateway Station
San Antonio Bus Station
No tags
Greyhound Lines, Inc. + Valley Transit
Bus
Gateway Station
San Antonio Bus Station
No tags
Bus
Gateway Station
San Antonio Bus Station
No tags
Last refresh of the prices: Yesterday at 7:57 PM CST.
Compare 2 ways to go from St. Louis to San Antonio
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach San Antonio. The journey takes about 22 hours 30 minutes and with fares starting at just $73, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from St. Louis to San Antonio, US by bus
What is the distance between St. Louis and San Antonio?
About 793 miles (1278 km) separate St. Louis and San Antonio.
What are the departure and arrival stations when taking the bus from St. Louis to San Antonio?
If you're headed to San Antonio from St. Louis, chances are that your bus will leave from Gateway Station and arrive at San Antonio Bus Station. These are the main departure and arrival locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in San Antonio?
Once in San Antonio, you can start exploring the city and discover its surroundings. The top sights and things to do are McNay Art Museum, Six Flags Fiesta Texas, The Alamo, Japanese Tea Garden and Ruby City.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$210
11/18
$202
Today
$198
11/20
$106
11/21
$181
11/22
$187
11/23
$175
11/24
$143
The cheapest trip from St. Louis to San Antonio, US was searched and found on Nov 20, 2025 with a price of $106
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to San Antonio, US, as early as possible.
You can expect to pay from $106 to $210 for a bus ticket from St. Louis to San Antonio, US based on the last 2 days. You can expect to find the cheapest price for the trip at $106 which is on 2025-11-20.
The cheapest trip from St. Louis to San Antonio, US was searched and found on Nov 20, 2025 with a price of $106
